(Q34646556)

3 August 2017

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title

Epigenetic gene silencing in cancer: the DNA hypermethylome (English)

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3 August 2017

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1

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3 August 2017

1 April 2007

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3 August 2017

Human Molecular Genetics

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3 August 2017

16 Spec No 1

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3 August 2017

R50-9

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Specific DNA methylation sites in the vicinity of the chicken beta-globin genes

3 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The necessity of a human epigenome project

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Towards the human cancer epigenome: a first draft of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Global histone modification patterns predict risk of prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA methylation profiling of human chromosomes 6, 20 and 22

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

CpG-rich islands and the function of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Role for DNA methylation in the control of cell type specific maspin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Comparative isoschizomer profiling of cytosine methylation: the HELP assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The DNA methylation paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

CpG methylation is maintained in human cancer cells lacking DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Cellular memory and the histone code

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Heterochromatin: stable and unstable invasions at home and abroad

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Polycomb silencers control cell fate, development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Aberrant DNA methylation as a cancer-inducing mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Gene-Expression Profiles in Hereditary Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Evidence for an instructive mechanism of de novo methylation in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

DNA motifs associated with aberrant CpG island methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Silencing of bidirectional promoters by DNA methylation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Chromatin signatures of pluripotent cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

The epigenetic progenitor origin of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Cancer epigenetics and methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Myc represses transcription through recruitment of DNA methyltransferase corepressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Aging and cancer: issues of basic and clinical science

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A-type lamins: guardians of the soma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Nuclear lamins: laminopathies and their role in premature ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

RecQ helicases: caretakers of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

How microRNAs control cell division, differentiation and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

MicroRNA expression profiles classify human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

MicroRNA signatures in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

RAS is regulated by the let-7 microRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM018

21 January 2018

Identifiers

DOI

10.1093/HMG/DDM018

1 reference

3 August 2017

1 reference

PubMed ID

17613547