(Q37264528)

19 August 2017

1 reference

title

Pharmacogenetic relevance of MTHFR polymorphisms (English)

1 reference

19 August 2017

Giuseppe Toffoli

1

1 reference

ORCID Public Data File 2021

author name string

Elena De Mattia

series ordinal

2

1 reference

19 August 2017

1 September 2008

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19 August 2017

1 reference

19 August 2017

9

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19 August 2017

9

1 reference

19 August 2017

1195-1206

1 reference

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

19 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Pharmacogenetic study of methylenetetrahydrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase and thymidylate synthase genotypes modify oral mucositis severity following hematopoietic stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

The pharmacogenetics of methotrexate in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Screening for new MTHFR polymorphisms and NTD risk

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case–control study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

Polymorphisms in Folate, Pyrimidine, and Purine Metabolism Are Associated with Efficacy and Toxicity of Methotrexate in Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1195

10.2217/14622416.9.9.1195

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18781847