(Q37293099)

19 August 2017

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title

Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications (English)

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19 August 2017

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Ola Didrik Saugstad

2

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author name string

Emin Maltepe

series ordinal

1

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PubMed ID

18852690

19 August 2017

language of work or name

English

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publication date

1 March 2009

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19 August 2017

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19 August 2017

65

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19 August 2017

3

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19 August 2017

261-268

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https://scigraph.springernature.com/pub.10.1203/pdr.0b013e31818fc83f

19 August 2017

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

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Archean Molecular Fossils and the Early Rise of Eukaryotes

21 January 2018

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21 January 2018

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Free radicals, mitochondria, and hypoxia-ischemia in the developing brain

21 January 2018

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HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.

21 January 2018

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Genetic models in applied physiology: invited review: effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest

21 January 2018

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Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy

21 January 2018

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Oxygen poisoning and x-irradiation: a mechanism in common

21 January 2018

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Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production

21 January 2018

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Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent

21 January 2018

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Oxygen radicals and pulmonary damage

21 January 2018

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Expression of NADPH oxidases and enhanced H(2)O(2)-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-alpha

21 January 2018

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Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production.

21 January 2018

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Toxic effects of oxygen on human embryo development

21 January 2018

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Factors affecting the developmental competence of mouse oocytes grown in vitro: oxygen concentration.

21 January 2018

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Culture of rabbit zygotes into blastocysts in protein-free medium with one to twenty per cent oxygen

21 January 2018

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Effects of oxygen toxicity on early development of mouse embryos

21 January 2018

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Intrauterine Oxygen Tension in the Rat During Progestation: Its Possible Relation to Carbohydrate Metabolism and the Regulation of Nidation

21 January 2018

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The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics.

21 January 2018

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Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited

21 January 2018

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Maternal circulation in the first-trimester human placenta--myth or reality?

21 January 2018

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Suspended Animation in C. elegans Requires the Spindle Checkpoint

21 January 2018

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Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans

21 January 2018

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Oxygen deprivation causes suspended animation in the zebrafish embryo

21 January 2018

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Tolerance to low O2: lessons from invertebrate genetic models

21 January 2018

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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HIF-1 and mechanisms of hypoxia sensing

21 January 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

21 January 2018

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

21 January 2018

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

21 January 2018

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ERK activation upon hypoxia: involvement in HIF-1 activation

21 January 2018

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Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes.

21 January 2018

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Mitochondrial regulation of oxygen sensing

21 January 2018

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

21 January 2018

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ARNT-deficient mice and placental differentiation

21 January 2018

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

21 January 2018

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

1 reference

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

21 January 2018

1 reference

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Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Regulation of human placental development by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

VEGFA is necessary for chondrocyte survival during bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Defective brain development in mice lacking the Hif-1alpha gene in neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Oxygen-reactive species and antioxidant responses during development: the metabolic paradox of cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Optimal oxygenation at birth and in the neonatal period

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

To oxygenate or not to oxygenate--that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Can Changes in Clinical Practice Decrease the Incidence of Severe Retinopathy of Prematurity in Very Low Birth Weight Infants?

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Avoiding hyperoxia in infants 1250 g is associated with improved short- and long-term outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Hypoxanthine as a Measurement of Hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

Plasma Hypoxanthine Concentrations in Pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31818FC83F

10.1203/PDR.0B013E31818FC83F

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

18852690

Dimensions Publication ID

19 August 2017

0 references

1 reference

PubMed ID

18852690