(Q37293337)

19 August 2017

1 reference

title

NF-kappaB signaling pathway and its therapeutic implications in human diseases (English)

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19 August 2017

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1

Fazlul H Sarkar

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19 August 2017

Yiwei Li

2

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19 August 2017

Zhiwei Wang

series ordinal

3

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19 August 2017

Dejuan Kong

series ordinal

4

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19 August 2017

publication date

1 January 2008

1 reference

International Reviews of Immunology

19 August 2017

published in

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19 August 2017

volume

27

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19 August 2017

issue

5

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19 August 2017

page(s)

293-319

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

19 August 2017

cites work

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

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Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes

21 January 2018

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Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB.

21 January 2018

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Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway

21 January 2018

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Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Transcription factor NF-kappaB as a potential biomarker for oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

The role of oxidative stress in mechanisms of metal-induced carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear factor-kappaB in cancer development and progression

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Oxidants, oxidative stress and the biology of ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Antioxidants, NFkappaB activation, and diabetogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Oxidatively modified proteins in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830180802276179

Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Activation of nuclear factor kappa B inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

NF-kappaB action in sepsis: the innate immune system and the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear factor-kappa B and cancer: its role in prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Mechanisms of disease: chronic inflammation and cancer in the pancreas--a potential role for pancreatic stellate cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inflammation and cancer: an ancient link with novel potentials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

NF-kappa B as a therapeutic target in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Direct regulation of TWIST by HIF-1alpha promotes metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Regulation of epithelial cell migration and tumor formation by beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Anti-inflammatory effects of flavonoids [etc.]

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Dietary intake of soy genistein is associated with lung function in patients with asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Molecular targets of dietary agents for prevention and therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Phase II trial of curcumin in patients with advanced pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Chemoprevention of colon cancer by Korean food plant components

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

A phase I study of indole-3-carbinol in women: tolerability and effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

In vivo reversal of doxorubicin resistance by (-)-epigallocatechin gallate in a solid human carcinoma xenograft

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Effects of resveratrol in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Resveratrol reduces renal and lung injury caused by sepsis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Resveratrol: preventing properties against vascular alterations and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Suppressed NF-kB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a induced apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Proteasome inhibition: a new anti-inflammatory strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Effects of nuclear factor-kappaB inhibitors and its implication on natural killer T-cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802276179

10.1080/08830180802276179

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference