(Q37299239)

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The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety

scientific article published on 15 October 2008

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Europe PubMed Central

19 August 2017

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Europe PubMed Central

The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety (English)

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Europe PubMed Central

19 August 2017

Alzheimer's disease

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Allen D Roses

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15 October 2008

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Neuropsychopharmacology

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19 August 2017

34

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6-17

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Europe PubMed Central

19 August 2017

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Europe PubMed Central

19 August 2017

https://scigraph.springernature.com/pub.10.1038/npp.2008.153

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Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease.

1 reference

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Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'

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A single-nucleotide polymorphism tagging set for human drug metabolism and transport

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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To kill a tumor cell: the potential of proapoptotic receptor agonists

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7 January 2021

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Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.

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7 January 2021

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Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

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7 January 2021

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Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

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7 January 2021

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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7 January 2021

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Parameters for reliable results in genetic association studies in common disease

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7 January 2021

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The DREAM trial – Authors' reply

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7 January 2021

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A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

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7 January 2021

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Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

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7 January 2021

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Conflicts of interest in health care: who guards the guardians?

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7 January 2021

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

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7 January 2021

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Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial.

1 reference

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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The new clinical trials with thiazolidinediones--DREAM, ADOPT, and CHICAGO: promises fulfilled?

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7 January 2021

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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7 January 2021

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Pharmacogenetics goes genomic

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7 January 2021

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

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7 January 2021

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

1 reference

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7 January 2021

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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7 January 2021

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Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

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7 January 2021

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Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

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7 January 2021

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A comprehensive review of genetic association studies

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Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility

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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

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7 January 2021

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Non-replication and inconsistency in the genome-wide association setting

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Charcot-Marie-Tooth neuropathies: diagnosis and management.

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7 January 2021

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Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families

1 reference

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7 January 2021

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The pathogenesis of spinocerebellar ataxia

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Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

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A 4-Mb high-density single nucleotide polymorphism-based map around human APOE

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The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort

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Paving the critical path: how can clinical pharmacology help achieve the vision?

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7 January 2021

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

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7 January 2021

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

1 reference

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7 January 2021

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Pharmacogenetics of psychotropic drug response

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7 January 2021

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HLA-B*5701 screening for hypersensitivity to abacavir

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

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Perspectives on the failure of pharmaceutical and medical device industries to fully protect public health interests.

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7 January 2021

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SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease

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7 January 2021

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Genome-wide association studies for complex traits: consensus, uncertainty and challenges

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7 January 2021

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A 60-year tale of spots, maps, and genes

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7 January 2021

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Mendelian Inheritance in Man and its online version, OMIM

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Association between SORL1 and Alzheimer's disease in a genome-wide study

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Priorities and standards in pharmacogenetic research

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7 January 2021

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

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7 January 2021

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Further Investigation of Linkage Disequilibrium SNPs and their Ability to Identify Associated Susceptibility Loci

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7 January 2021

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DNA vaccine therapy for Alzheimer's disease: present status and future direction

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7 January 2021

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The experience with voluntary genomic data submissions at the FDA and a vision for the future of the voluntary data submission program

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Further evidence of genetic heterogeneity in autosomal dominant distal motor neuronopathy

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7 January 2021

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Preventing postmarketing changes in recommended doses and marketing withdrawals.

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7 January 2021

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Pharmacogenetics and the potential for the individualization of antiretroviral therapy

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https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Trends in development and approval times for new therapeutics in the United States

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Stimulation of cholecystokinin-A receptors with Gl181771X: a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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From genes to mechanisms to therapies: lessons to be learned from neurological disorders

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Pharmacogenetics and drug development: the path to safer and more effective drugs

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Genome-wide screening for drug discovery and companion diagnostics.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Spinal muscular atrophy: clinical classification and disease heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Presenilin: running with scissors in the membrane

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Pharmacogenetic studies in depression: a proposal for methodologic guidelines

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

inferred from DOI database lookup

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

inferred from DOI database lookup

Avid binding of beta A amyloid peptide to its own precursor

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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A beta oligomers - a decade of discovery

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

based on heuristic

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The development of pro-apoptotic cancer therapeutics

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https://api.crossref.org/works/10.1038%2FNPP.2008.153

7 January 2021

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Identifiers

10.1038/NPP.2008.153

1 reference

Europe PubMed Central

19 August 2017

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0 references

1 reference

Europe PubMed Central

19 August 2017

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