(Q37299286)

19 August 2017

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title

PGC-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions (English)

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19 August 2017

2

David C Wright

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19 August 2017

Carley R Benton

1

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PubMed ID

18923559

19 August 2017

Arend Bonen

series ordinal

3

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19 August 2017

1 October 2008

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Applied Physiology, Nutrition, and Metabolism

19 August 2017

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19 August 2017

33

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19 August 2017

5

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19 August 2017

843-862

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Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway

19 August 2017

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Functional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imaging

21 January 2018

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21 January 2018

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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

21 January 2018

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The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle

21 January 2018

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Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

21 January 2018

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Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle

21 January 2018

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Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria

21 January 2018

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Free fatty acids, insulin resistance, and type 2 diabetes mellitus

21 January 2018

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Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

21 January 2018

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Benefits of exercise for type II diabetics: convergence of epidemiologic, physiologic, and molecular evidence

21 January 2018

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Lipid metabolism, exercise and insulin action.

21 January 2018

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Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity

21 January 2018

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Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake

21 January 2018

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Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise

21 January 2018

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

21 January 2018

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Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression.

21 January 2018

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Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise

21 January 2018

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Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

21 January 2018

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Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

21 January 2018

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Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

21 January 2018

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

21 January 2018

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cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats

21 January 2018

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Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance

21 January 2018

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Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

21 January 2018

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Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

21 January 2018

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

21 January 2018

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Biochemical Adaptations to Endurance Exercise in Muscle

21 January 2018

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PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein

21 January 2018

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Skeletal muscle lipid metabolism with obesity

21 January 2018

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PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations

21 January 2018

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

21 January 2018

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Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo

21 January 2018

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Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

21 January 2018

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Fuel selection in human skeletal muscle in insulin resistance: a reexamination

21 January 2018

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Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus

21 January 2018

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

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A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

21 January 2018

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Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

21 January 2018

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21 January 2018

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

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Cloning and mRNA tissue distribution of human PPARgamma coactivator-1.

21 January 2018

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cAMP elevating agents suppress secretory phospholipase A(2)-induced matrix metalloproteinase-2 activation

21 January 2018

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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

21 January 2018

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PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

21 January 2018

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

21 January 2018

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Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor

21 January 2018

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

21 January 2018

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PGC-1beta in the regulation of hepatic glucose and energy metabolism

21 January 2018

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 January 2018

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Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

21 January 2018

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Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

21 January 2018

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 January 2018

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Changes in fatty acid transport and transporters are related to the severity of insulin deficiency

21 January 2018

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Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

21 January 2018

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Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo

21 January 2018

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

21 January 2018

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Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles

21 January 2018

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Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP

21 January 2018

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Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids

21 January 2018

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

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PGC-1β is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family

21 January 2018

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PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle.

21 January 2018

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Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle

21 January 2018

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Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway.

21 January 2018

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The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks.

21 January 2018

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

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Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

21 January 2018

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Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

21 January 2018

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An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians

21 January 2018

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Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

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Activation of PPARgamma coactivator-1 through transcription factor docking

21 January 2018

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Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

21 January 2018

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

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Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes.

21 January 2018

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Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

21 January 2018

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

21 January 2018

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PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

21 January 2018

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Skeletal muscle glucose uptake during exercise: how is it regulated?

21 January 2018

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Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.

21 January 2018

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Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner

21 January 2018

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Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms

21 January 2018

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Invited review: intracellular signaling in contracting skeletal muscle

21 January 2018

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Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

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PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

21 January 2018

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Nuclear activators and coactivators in mammalian mitochondrial biogenesis

21 January 2018

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Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

21 January 2018

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A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

21 January 2018

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LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training

21 January 2018

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Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

21 January 2018

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Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance

21 January 2018

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Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid

21 January 2018

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Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

21 January 2018

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Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

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Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: effects of time and intensity

21 January 2018

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Effects of acute bouts of running and swimming exercise on PGC-1α protein expression in rat epitrochlearis and soleus muscle

21 January 2018

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Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

21 January 2018

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Effects of high-intensity intermittent swimming on PGC-1alpha protein expression in rat skeletal muscle

21 January 2018

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Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation

21 January 2018

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Turning signals on and off: GLUT4 traffic in the insulin-signaling highway

21 January 2018

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Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

21 January 2018

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Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

21 January 2018

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Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes.

21 January 2018

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Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance

21 January 2018

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Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha

21 January 2018

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Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes

21 January 2018

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A role for the transcriptional coactivator PGC-1alpha in muscle refueling

21 January 2018

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Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion

21 January 2018

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Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression

21 January 2018

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

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Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans

21 January 2018

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Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/H08-074

1 reference

19 August 2017

1 reference

PubMed ID

18923559