(Q37304596)

English

Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy

scientific article published on 03 February 2009

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scholarly article

1 reference

Europe PubMed Central

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20 January 2020

Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19190324%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

multiple myeloma

1 reference

based on heuristic

inferred from title

Julio Aguirre-Ghiso

2

1 reference

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20 January 2020

author name string

Denis M Schewe

1

1 reference

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20 January 2020

language of work or name

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publication date

3 February 2009

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Europe PubMed Central

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20 January 2020

Cancer Research

1 reference

Europe PubMed Central

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20 January 2020

69

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20 January 2020

1545-1552

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20 January 2020

4

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20 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2726651/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

1 reference

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Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

1 reference

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6 September 2017

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma

1 reference

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6 September 2017

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

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Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation

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ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

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GRP78 induction in cancer: therapeutic and prognostic implications.

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6 September 2017

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

1 reference

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6 September 2017

Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.

1 reference

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6 September 2017

Proteasome inhibitor therapy in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

6 September 2017

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

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6 September 2017

Regulation of antioxidant metabolism by translation initiation factor 2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

6 September 2017

PERK mediates cell-cycle exit during the mammalian unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

6 September 2017

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

6 September 2017

Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

14 September 2017

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

1 reference

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14 September 2017

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

14 September 2017

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

14 September 2017

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

14 September 2017

Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

14 September 2017

Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

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14 September 2017

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

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ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK).

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Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succinimidyl ester, a stably integrated fluorescent probe.

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Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

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Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

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Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726651

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Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19190324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

That which does not kill me makes me stronger: adapting to chronic ER stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19190324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-3858

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19190324%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19190324%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19190324%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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