(Q36845355)

16 August 2017

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title

Inhibitors of the heat shock response: biology and pharmacology (English)

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16 August 2017

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2

Paul Workman

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16 August 2017

Marissa V Powers

1

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16 August 2017

language of work or name

English

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publication date

25 May 2007

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16 August 2017

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16 August 2017

volume

581

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16 August 2017

issue

19

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16 August 2017

page(s)

3758-3769

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Pathways of chaperone-mediated protein folding in the cytosol

16 August 2017

cites work

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Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

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PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

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Chaperones increase association of tau protein with microtubules

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Hsp70s contain a specific sulfogalactolipid binding site. Differential aglycone influence on sulfogalactosyl ceramide binding by recombinant prokaryotic and eukaryotic hsp70 family members

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Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

21 January 2018

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

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Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

21 January 2018

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Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

21 January 2018

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The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

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The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function

21 January 2018

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Hsp90 inhibitors identified from a library of novobiocin analogues

21 January 2018

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Rational design of shepherdin, a novel anticancer agent.

21 January 2018

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Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.

21 January 2018

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Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

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Hsp90: the vulnerable chaperone

21 January 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

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Histone modification enzymes: novel targets for cancer drugs

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Recombinant antibodies: a natural partner in combinatorial antifungal therapy

21 January 2018

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Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

21 January 2018

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Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation

21 January 2018

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Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

21 January 2018

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Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

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Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead

21 January 2018

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In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

21 January 2018

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A New Antifungal Substance of Fungal Origin

21 January 2018

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10.1016/J.FEBSLET.2007.05.040

21 January 2018

Identifiers

DOI

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16 August 2017

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