(Q37309256)

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Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection

scientific article published on May 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 August 2017

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Europe PubMed Central

Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Mycobacterium tuberculosis

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Tom H M Ottenhoff

2

object named as

Tom H M Ottenhoff

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Europe PubMed Central

PubMed publication ID

19 August 2017

author name string

May Young Lin

1

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Europe PubMed Central

PubMed publication ID

19 August 2017

publication date

1 May 2008

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Europe PubMed Central

PubMed publication ID

19 August 2017

Biological Chemistry

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Europe PubMed Central

PubMed publication ID

19 August 2017

389

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Europe PubMed Central

PubMed publication ID

19 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

497-511

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

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Tuberculosis vaccines - an update.

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Vaccine strategies against latent tuberculosis infection

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Transcription and autoregulation of the Rv3134c-devR-devS operon of Mycobacterium tuberculosis

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Pathogenesis of tuberculosis: pathway to apical localization

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Comparative genomics of BCG vaccines by whole-genome DNA microarray

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Susceptibility to mycobacterial infections: the importance of host genetics

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Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans

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Human immunity to M. tuberculosis: T cell subsets and antigen processing

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Mycobacterium bovis BCG response regulator essential for hypoxic dormancy

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Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model

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Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates

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Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids

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Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture

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Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis

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Antibody profiles characteristic of Mycobacterium tuberculosis infection state

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Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

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Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism

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Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro

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Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis

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A novel antioxidant gene from Mycobacterium tuberculosis

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In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions.

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NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis

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Variation in protection by BCG: implications of and for heterologous immunity

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BCG: the challenge continues

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Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins

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A family of acr-coregulated Mycobacterium tuberculosis genes shares a common DNA motif and requires Rv3133c (dosR or devR) for expression.

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Tuberculosis: latency and reactivation

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Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice

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Identifying putative Mycobacterium tuberculosis Rv2004c protein sequences that bind specifically to U937 macrophages and A549 epithelial cells

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Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.

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Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease

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Mycobacteria target DC-SIGN to suppress dendritic cell function

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T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination

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Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.

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Pattern recognition receptors: doubling up for the innate immune response

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Selection of a human T helper type 1-like T cell subset by mycobacteria

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The immune response to BCG vaccination of newborns

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Mycobacterial manipulation of the host cell

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Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivo

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Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis

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Tumor necrosis factor is critical to control tuberculosis infection

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Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

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How can immunology contribute to the control of tuberculosis?

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The contribution of immunology to the rational design of novel antibacterial vaccines

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Interplay between mycobacteria and host signalling pathways

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TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

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Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

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Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

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Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis

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Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

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Nitric oxide and macrophage function

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Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis

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Identification of gene targets against dormant phase Mycobacterium tuberculosis infections

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Gene expression profile of Mycobacterium tuberculosis in a non-replicating state

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Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis

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Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

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Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.

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Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.

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The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated

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Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis

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Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice.

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Th2 cytokines in susceptibility to tuberculosis.

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Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins

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Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice

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Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis

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DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.

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Type II alveolar cells play roles in macrophage-mediated host innate resistance to pulmonary mycobacterial infections by producing proinflammatory cytokines

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

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Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance

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Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

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Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence

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Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration

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Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress

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Advances in tuberculosis vaccine strategies

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Regulation of nitrate reductase activity in Mycobacterium tuberculosis by oxygen and nitric oxide

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Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis

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Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions

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Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients

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Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa

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Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension

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Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection

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Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis

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Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode

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Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae

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Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment.

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Immune responses to mycobacterial antigens in the Gambian population: implications for vaccines and immunodiagnostic test design

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Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program

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Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy

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Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis

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Nonreplicating persistence of mycobacterium tuberculosis

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Human T- and B-cell reactivity to the 16kDa alpha-crystallin protein of Mycobacterium tuberculosis

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A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis

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The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages

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Defining putative T cell epitopes from PE and PPE families of proteins of Mycobacterium tuberculosis with vaccine potential

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Increased pathology in lungs of mice after infection with an alpha-crystallin mutant of Mycobacterium tuberculosis: changes in cathepsin proteases and certain cytokines

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Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

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21 January 2018

Identifiers

10.1515/BC.2008.057

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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