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English
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.
scientific article published on 22 April 2009
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scholarly article
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Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
title
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
main subject
mitochondrion
1 reference
based on heuristic
inferred from title
lifetime
1 reference
based on heuristic
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author
Natascia Ventura
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
Alfonso Schiavi
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
Thomas Johnson
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6
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
Alessandro Torgovnick
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4
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Alessandro Torgovnick
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Europe PubMed Central
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27 January 2020
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
PMCID
2730656
Shane L Rea
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2
object named as
Shane L Rea
1 reference
stated in
Europe PubMed Central
retrieved
27 January 2020
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
PMCID
2730656
author name string
Roberto Testi
series ordinal
5
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stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
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27 January 2020
publication date
22 April 2009
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2730656
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retrieved
27 January 2020
published in
Aging Cell
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Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
volume
8
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Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
page(s)
380-393
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Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
issue
4
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stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
cites work
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Autophagy in the Pathogenesis of Disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Structural evolution of C-terminal domains in the p53 family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Two neurons mediate diet-restriction-induced longevity in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
p53: new roles in metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Janus-faced autophagy: a dual role of cellular self-eating in neurodegeneration?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
p53 in health and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Hormesis and aging in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
New tricks of an old molecule: lifespan regulation by p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
p53 regulates mitochondrial respiration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Metabolism in the Caenorhabditis elegans Mit mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Autophagy genes are essential for dauer development and life-span extension in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Genome-wide RNAi screening in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Direct observation of stress response in Caenorhabditis elegans using a reporter transgene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Caspase and calpain substrates: roles in synaptic plasticity and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
6 September 2017
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
14 September 2017
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
14 September 2017
Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
28 September 2017
p53: The Janus of autophagy?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
26 June 2018
Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
26 June 2018
Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
26 June 2018
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Mutations that increase the life span of C. elegans inhibit tumor growth.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
The fatty acid synthase gene is a conserved p53 family target from worm to human.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
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Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Rates of behavior and aging specified by mitochondrial function during development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Mitochondrial genome content is regulated during nematode development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
2 September 2018
The effects of p53 on whole organism longevity are mediated by autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
20 October 2018
Delayed ageing through damage protection by the Arf/p53 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730656
retrieved
3 December 2018
Identifiers
DOI
10.1111/J.1474-9726.2009.00482.X
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
PMCID
2730656
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
PubMed ID
19416129
1 reference
stated in
Europe PubMed Central
PMCID
2730656
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416129%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 January 2020
ResearchGate publication ID
24402363
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