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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.
scientific article published on 13 October 2016
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
title
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
main subject
Nicotinamide nucleotide adenylyltransferase 1
1 reference
stated in
GOA release 2020-03-11
Sterile alpha and HEAT/Armadillo motif containing 1
1 reference
stated in
GOA release 2020-03-11
author
Yo Sasaki
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
Takashi Nakagawa
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
Aaron DiAntonio
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
Jeffrey Milbrandt
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
author name string
Xianrong Mao
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
language of work or name
English
0 references
publication date
13 October 2016
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
published in
eLife
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
volume
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5063586/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
SARM1 activation triggers axon degeneration locally via NAD⁺ destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Absence of SARM1 rescues development and survival of NMNAT2-deficient axons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Wallerian degeneration: an emerging axon death pathway linking injury and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Sarm1-mediated axon degeneration requires both SAM and TIR interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Axon degeneration: Molecular mechanisms of a self-destruction pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Axon degeneration mechanisms: commonality amid diversity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
A local mechanism mediates NAD-dependent protection of axon degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
6 September 2017
Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
14 September 2017
Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063586
retrieved
2 September 2018
Evidence for a physiologically active nicotinamide phosphoribosyltransferase in cultured human fibroblasts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27735788
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Formation of [nicotinamide-²H₃]NAD⁺ from [²H₄]nicotinamide and [²H₄]nicotinic acid in human HepG2N cells and involvement of ²H/¹H exchange at the redox site of NAD⁺/NADH
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27735788
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.7554/ELIFE.19749
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
PMC publication ID
5063586
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
PubMed publication ID
27735788
1 reference
stated in
Europe PubMed Central
PMC publication ID
5063586
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27735788%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 March 2020
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