(Q38212791)

31 August 2017

Wallerian degeneration: an emerging axon death pathway linking injury and disease (English)

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31 August 2017

Laura Conforti

1

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31 August 2017

Jonathan Gilley

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2

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31 August 2017

Michael P Coleman

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3

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31 August 2017

language of work or name

English

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publication date

1 June 2014

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Nature Reviews Neuroscience

31 August 2017

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31 August 2017

15

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31 August 2017

6

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31 August 2017

394-409

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https://scigraph.springernature.com/pub.10.1038/nrn3680

31 August 2017

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The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves

21 January 2018

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

21 January 2018

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

21 January 2018

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The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction

21 January 2018

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Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo

21 January 2018

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Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

21 January 2018

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Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

21 January 2018

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Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

21 January 2018

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Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

21 January 2018

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Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.

21 January 2018

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Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo

21 January 2018

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons

21 January 2018

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Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning

21 January 2018

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The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein

21 January 2018

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The challenges of axon survival: introduction to the special issue on axonal degeneration

21 January 2018

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WldS mice are resistant to paclitaxel (taxol) neuropathy

21 January 2018

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Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

21 January 2018

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Axon degeneration mechanisms: commonality amid diversity

21 January 2018

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The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease

21 January 2018

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Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres

21 January 2018

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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

21 January 2018

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The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

21 January 2018

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Neurites can remain viable after destruction of the neuronal soma by programmed cell death (apoptosis).

21 January 2018

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The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy

21 January 2018

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Apoptosis: a review of programmed cell death

21 January 2018

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Early course of Wallerian degeneration in myelinated fibres of the rat phrenic nerve

21 January 2018

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The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy.

21 January 2018

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A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses

21 January 2018

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Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning

21 January 2018

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Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

21 January 2018

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A local mechanism mediates NAD-dependent protection of axon degeneration

21 January 2018

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Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.

21 January 2018

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Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).

21 January 2018

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A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity

21 January 2018

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Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

21 January 2018

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Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway

21 January 2018

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

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A caspase cascade regulating developmental axon degeneration

21 January 2018

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Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals

21 January 2018

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 January 2018

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Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function

21 January 2018

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration

21 January 2018

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Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

21 January 2018

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Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

21 January 2018

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Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

21 January 2018

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Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

21 January 2018

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NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration

21 January 2018

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NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

21 January 2018

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Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

21 January 2018

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Maintaining energy homeostasis is an essential component of Wld(S)-mediated axon protection

21 January 2018

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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

21 January 2018

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

21 January 2018

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NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

21 January 2018

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Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway

21 January 2018

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CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

21 January 2018

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Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila

21 January 2018

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Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.

21 January 2018

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Sarm1-mediated axon degeneration requires both SAM and TIR interactions

21 January 2018

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Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin

21 January 2018

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MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

21 January 2018

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Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains.

21 January 2018

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SCG10 is a JNK target in the axonal degeneration pathway.

21 January 2018

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A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

21 January 2018

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Differential distribution of stathmin and SCG10 in developing neurons in culture.

21 January 2018

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Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles

21 January 2018

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Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration

21 January 2018

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ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

21 January 2018

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N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration

21 January 2018

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Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration

21 January 2018

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Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons.

21 January 2018

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Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

21 January 2018

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Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.

21 January 2018

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A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

21 January 2018

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Mitochondria as a central sensor for axonal degenerative stimuli.

21 January 2018

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Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential

21 January 2018

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Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.

21 January 2018

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WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering

21 January 2018

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WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury

21 January 2018

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Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration

21 January 2018

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Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues

21 January 2018

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Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria

21 January 2018

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Vesicular glycolysis provides on-board energy for fast axonal transport

21 January 2018

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Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

21 January 2018

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T-cell death following immune activation is mediated by mitochondria-localized SARM.

21 January 2018

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Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death

21 January 2018

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Axonal degeneration is mediated by the mitochondrial permeability transition pore.

21 January 2018

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WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity

21 January 2018

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Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress

21 January 2018

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Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent.

21 January 2018

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Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss

21 January 2018

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Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

21 January 2018

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Oxidants, oxidative stress and the biology of ageing

21 January 2018

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The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration

21 January 2018

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The Wld(S) mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathway in vivo

21 January 2018

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Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

21 January 2018

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The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina

21 January 2018

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An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

21 January 2018

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The neuroprotective factor Wld(s) fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy

21 January 2018

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The Wallerian degeneration slow (Wld(s)) gene does not attenuate disease in a mouse model of spinal muscular atrophy

21 January 2018

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Mutations in a P-type ATPase gene cause axonal degeneration

21 January 2018

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WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis

21 January 2018

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Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

21 January 2018

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Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice.

21 January 2018

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Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction

21 January 2018

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Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters

21 January 2018

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Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1

21 January 2018

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A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

21 January 2018

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Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle.

21 January 2018

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Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.

21 January 2018

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The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

21 January 2018

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Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo

21 January 2018

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The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

21 January 2018

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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

21 January 2018

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Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

21 January 2018

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Ubiquitination-dependent mechanisms regulate synaptic growth and function.

21 January 2018

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Further Studies on Motor and Sensory Nerve Regeneration in Mice With Delayed Wallerian Degeneration

21 January 2018

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Efficient retrograde transport of pseudorabies virus within neurons requires local protein synthesis in axons

21 January 2018

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Axonal transport of adeno-associated viral vectors is serotype-dependent

21 January 2018

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Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis

21 January 2018

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Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection

21 January 2018

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Animal models of peripheral neuropathies

21 January 2018

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Axonal damage: a key predictor of outcome in human CNS diseases

21 January 2018

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Will the real multiple sclerosis please stand up?

21 January 2018

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Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.

21 January 2018

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Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X

21 January 2018

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Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

21 January 2018

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NMNAT1 mutations cause Leber congenital amaurosis

21 January 2018

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Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

21 January 2018

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Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy

21 January 2018

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Enzymology of NAD+ homeostasis in man.

21 January 2018

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Diversification of NAD biological role: the importance of location

21 January 2018

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

21 January 2018

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The NAMPT inhibitor FK866 reverts the damage in spinal cord injury

21 January 2018

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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

21 January 2018

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Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury

21 January 2018

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The evolutionary portrait of metazoan NAD salvage

21 January 2018

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The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.

21 January 2018

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Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.

21 January 2018

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Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.

21 January 2018

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Prion disease development in slow Wallerian degeneration (Wld(S)) mice.

21 January 2018

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Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.

21 January 2018

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Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease

21 January 2018

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Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

21 January 2018

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Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

31 March 2020

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

31 March 2020

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Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

31 March 2020

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The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.

31 March 2020

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Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels

31 March 2020

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A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

31 March 2020

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Wld(S) protects against peripheral neuropathy and retinopathy in an experimental model of diabetes in mice

31 March 2020

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Protective role of Wallerian degeneration slow (Wld(s)) gene against retinal ganglion cell body damage in a Wallerian degeneration model

31 March 2020

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The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN3680

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Dimensions Publication ID

31 August 2017

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