(Q37338992)

19 August 2017

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title

Nucleic acids-based therapeutics in the battle against pathogenic viruses (English)

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19 August 2017

Joost Haasnoot

1

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PubMed ID

19048203

19 August 2017

Ben Berkhout

series ordinal

2

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19 August 2017

1 January 2009

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Handbook of experimental pharmacology

19 August 2017

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19 August 2017

189

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19 August 2017

243-263

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Induction and suppression of RNA silencing: insights from viral infections

19 August 2017

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12 December 2020

Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs

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12 December 2020

Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase

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12 December 2020

Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration

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12 December 2020

The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat

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12 December 2020

Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

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12 December 2020

A randomized controlled clinical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS.

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12 December 2020

Human immunodeficiency virus type 1 escape from RNA interference

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12 December 2020

Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins

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12 December 2020

Modulation of HIV-1 replication by RNA interference

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12 December 2020

A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.

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12 December 2020

Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients

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12 December 2020

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

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12 December 2020

Suppression of microRNA-silencing pathway by HIV-1 during virus replication

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12 December 2020

Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.

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12 December 2020

Design of expression vectors for RNA interference based on miRNAs and RNA splicing.

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12 December 2020

Small interfering RNA Inhibits Hepatitis B virus replication in mice

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12 December 2020

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

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12 December 2020

A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication

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12 December 2020

Second-generation shRNA libraries covering the mouse and human genomes

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12 December 2020

Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.

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12 December 2020

Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA.

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12 December 2020

Protection against lethal influenza virus challenge by RNA interference in vivo.

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12 December 2020

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

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12 December 2020

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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12 December 2020

Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype

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12 December 2020

Antisense properties of peptide nucleic acid

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12 December 2020

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

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12 December 2020

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells

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12 December 2020

Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5

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12 December 2020

Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

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12 December 2020

Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition

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12 December 2020

Short interfering RNA-directed inhibition of hepatitis B virus replication

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12 December 2020

Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA.

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture

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12 December 2020

A specificity comparison of four antisense types: morpholino, 2'-O-methyl RNA, DNA, and phosphorothioate DNA

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12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

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12 December 2020

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

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12 December 2020

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

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12 December 2020

Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase

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12 December 2020

Improved silencing properties using small internally segmented interfering RNAs

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12 December 2020

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

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12 December 2020

Silencing of HIV-1 with RNA interference: a multiple shRNA approach

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12 December 2020

Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro

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12 December 2020

Oligonucleotides as antivirals: dream or realistic perspective?

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12 December 2020

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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12 December 2020

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

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12 December 2020

Aptamers in the virologists' toolkit

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12 December 2020

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

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12 December 2020

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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12 December 2020

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

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12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

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12 December 2020

Suppression of RNA interference by adenovirus virus-associated RNA.

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

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12 December 2020

Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference

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12 December 2020

Induction of an interferon response by RNAi vectors in mammalian cells

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12 December 2020

Identification of host proteins required for HIV infection through a functional genomic screen

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12 December 2020

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

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12 December 2020

Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

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12 December 2020

Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA.

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12 December 2020

Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome

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12 December 2020

Inhibition of SARS-associated coronavirus infection and replication by RNA interference.

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12 December 2020

Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

Prospects for antiviral ribozymes and deoxyribozymes

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12 December 2020

RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase

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12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

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12 December 2020

siRNA-directed inhibition of HIV-1 infection

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12 December 2020

Off-target effects by siRNA can induce toxic phenotype

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12 December 2020

A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs

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12 December 2020

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

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12 December 2020

LNA: a versatile tool for therapeutics and genomics

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12 December 2020

Inhibition of HIV-1 fusion with small interfering RNAs targeting the chemokine coreceptor CXCR4.

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12 December 2020

Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

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12 December 2020

RNA interference as an antiviral approach: targeting HIV-1.

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12 December 2020

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

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12 December 2020

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

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12 December 2020

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

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12 December 2020

Cross-clade inhibition of recombinant human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVcpz reverse transcriptases by RNA pseudoknot aptamers

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12 December 2020

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

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12 December 2020

A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon

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12 December 2020

DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells

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12 December 2020

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

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12 December 2020

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

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12 December 2020

Illuminating the silence: understanding the structure and function of small RNAs

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12 December 2020

Gene transfer in humans using a conditionally replicating lentiviral vector

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12 December 2020

Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells

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12 December 2020

Inhibition of replication and infection of severe acute respiratory syndrome-associated coronavirus with plasmid-mediated interference RNA.

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12 December 2020

Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation

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12 December 2020

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

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12 December 2020

Is RNA interference involved in intrinsic antiviral immunity in mammals?

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12 December 2020

Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference

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12 December 2020

Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells

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12 December 2020

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

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12 December 2020

Silencing of hepatitis A virus infection by small interfering RNAs

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12 December 2020

Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells

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12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

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12 December 2020

Inhibition of SARS-CoV replication by siRNA.

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12 December 2020

RNA interference against viruses: strike and counterstrike

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12 December 2020

Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs

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12 December 2020

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference

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12 December 2020

A general purpose RNA-cleaving DNA enzyme

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12 December 2020

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

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12 December 2020

Hepatitis B virus is inhibited by RNA interference in cell culture and in mice

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12 December 2020

Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo

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12 December 2020

Design of extended short hairpin RNAs for HIV-1 inhibition

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12 December 2020

EsiRNAs inhibit Hepatitis B virus replication in mice model more efficiently than synthesized siRNAs

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12 December 2020

A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients

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12 December 2020

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

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12 December 2020

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

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12 December 2020

Inhibition of HBV replication by siRNA in a stable HBV-producing cell line

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12 December 2020

Inhibition of hepatitis B virus in mice by RNA interference

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12 December 2020

RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant.

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

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12 December 2020

Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

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12 December 2020

Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells

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12 December 2020

Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

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12 December 2020

Selective inhibition of hepatitis B virus replication by RNA interference

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12 December 2020

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

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12 December 2020

Noise amidst the silence: off-target effects of siRNAs?

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12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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12 December 2020

Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery

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12 December 2020

Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A

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12 December 2020

10.1007/978-3-540-79086-0_9

Identifiers

DOI

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19 August 2017

1 reference

PubMed ID

19048203