(Q37348839)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

0 references

0 references

3

1 reference

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1 February 2020

author name string

George P Christophi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Michael Panos

2

1 reference

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1 February 2020

Chriso Tsikkou

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Cornelia Mihai

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Luis J Mejico

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Burk Jubelt

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Paul T Massa

8

1 reference

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1 February 2020

publication date

25 June 2009

1 reference

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1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

133

1 reference

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1 February 2020

issue

1

1 reference

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1 February 2020

page(s)

27-44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

1 February 2020

cites work

1 reference

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Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

6 September 2017

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Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis

6 September 2017

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6 September 2017

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Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia

6 September 2017

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6 September 2017

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SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.

6 September 2017

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Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection

6 September 2017

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6 September 2017

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Complex modulation of cell type-specific signaling in response to type I interferons

6 September 2017

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Drug Insight: interferon treatment in multiple sclerosis.

6 September 2017

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Therapeutic role of beta-interferons in multiple sclerosis

6 September 2017

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STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

6 September 2017

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Mechanisms of type-I- and type-II-interferon-mediated signalling

6 September 2017

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Neuropathology of multiple sclerosis-new concepts.

6 September 2017

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The effect of phosphatases SHP-1 and SHIP-1 on signaling by the ITIM- and ITAM-containing Fcgamma receptors FcgammaRIIB and FcgammaRIIA

6 September 2017

1 reference

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The function of the protein tyrosine phosphatase SHP-1 in cancer

6 September 2017

1 reference

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src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation

6 September 2017

1 reference

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Interferon gamma and interleukin 4 producing T cells in peripheral blood of multiple sclerosis patients undergoing immunomodulatory treatment

6 September 2017

1 reference

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Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase

6 September 2017

1 reference

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The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

6 September 2017

1 reference

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Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus

6 September 2017

1 reference

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6 September 2017

1 reference

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Development of a sensitive multi-well colorimetric assay for active NFkappaB

6 September 2017

1 reference

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Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter

6 September 2017

1 reference

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6 September 2017

1 reference

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Signaling pathways activated by interferons

6 September 2017

1 reference

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Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology.

6 September 2017

1 reference

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Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses

6 September 2017

1 reference

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Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons

6 September 2017

1 reference

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The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-gamma signaling in neural cells

6 September 2017

1 reference

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Defining the clinical course of multiple sclerosis: Results of an international survey

6 September 2017

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Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor

6 September 2017

1 reference

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Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

6 September 2017

1 reference

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Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase

6 September 2017

1 reference

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Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

6 September 2017

1 reference

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Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways

6 September 2017

1 reference

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TRAIL, CXCL10 and CCL2 plasma levels during long-term Interferon-beta treatment of patients with multiple sclerosis correlate with flu-like adverse effects but do not predict therapeutic response.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

PU.1 activates transcription of SHP-1 gene in hematopoietic cells

14 September 2017

1 reference

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IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites

14 September 2017

1 reference

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SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasis

14 September 2017

1 reference

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Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis.

14 September 2017

1 reference

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Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis

14 September 2017

1 reference

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SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling

14 September 2017

1 reference

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Molecular mechanisms underlying SHP-1 gene expression

28 September 2017

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Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray

28 September 2017

1 reference

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Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.

28 September 2017

1 reference

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Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.

28 September 2017

1 reference

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Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals.

28 September 2017

1 reference

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Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1.

28 September 2017

1 reference

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CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

26 June 2018

1 reference

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TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.

26 June 2018

1 reference

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Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B.

26 June 2018

1 reference

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Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice

26 June 2018

1 reference

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Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Inhibitory receptors, ITIM sequences and phosphatases

26 June 2018

1 reference

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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

26 June 2018

1 reference

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MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.

26 June 2018

1 reference

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The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

2 September 2018

1 reference

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IFN-beta1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression.

2 September 2018

1 reference

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Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Human recombinant PLD2 can repress p65 activity of guinea pigs of chronic asthma in vivo.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Interferon-beta-1 b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Arginase and autoimmune inflammation in the central nervous system

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Transcriptional activity of the SHP-1 gene in MCF7 cells is differentially regulated by binding of NF-Y factor to two distinct CCAAT-elements

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Human Protein Tyrosine Phosphatase 1C (PTPN6) Gene Structure: Alternate Promoter Usage and Exon Skipping Generate Multiple Transcripts

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2744840

Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1

3 December 2018

1 reference

12 December 2020

Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis

1 reference

12 December 2020

Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group

1 reference

12 December 2020

Cytokine secretion profile of myelin basic protein-specific T cells in multiple sclerosis

1 reference

12 December 2020

Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia

1 reference

12 December 2020

Type 1 interferons cool the inflamed brain

1 reference

12 December 2020

Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease

1 reference

12 December 2020

Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis

1 reference

12 December 2020

Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b

1 reference

12 December 2020

Interferon regulatory factor element and interferon regulatory factor 1 in the induction of major histocompatibility complex class I genes in neural cells

1 reference

12 December 2020

IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event

1 reference

12 December 2020

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b

1 reference

12 December 2020

Expression and function of the protein tyrosine phosphatase SHP-1 in oligodendrocytes

1 reference

12 December 2020

10.1016/J.CLIM.2009.05.019

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19559654%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

19559654

1 reference