(Q37358180)

19 August 2017

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title

Role of flagellin in Crohn's disease: emblematic of the progress and enigmas in understanding inflammatory bowel disease (English)

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inflammatory bowel diseases

19 August 2017

main subject

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2

Andrew T Gewirtz

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19 August 2017

Matam Vijay-Kumar

1

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19 August 2017

publication date

1 May 2009

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Inflammatory Bowel Diseases

19 August 2017

published in

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19 August 2017

volume

15

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19 August 2017

issue

5

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19 August 2017

page(s)

789-795

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Evolution of mammals and their gut microbes

19 August 2017

cites work

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Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

21 January 2018

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Molecular architecture of bacterial flagellum

21 January 2018

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Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

21 January 2018

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Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella.

21 January 2018

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Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

21 January 2018

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Flagellin-independent regulation of chemokine host defense in Campylobacter jejuni-infected intestinal epithelium

21 January 2018

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Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity

21 January 2018

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

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Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

21 January 2018

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Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

21 January 2018

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Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway

21 January 2018

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

21 January 2018

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IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function.

21 January 2018

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

21 January 2018

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Bacterial flagellin is a dominant antigen in Crohn disease.

21 January 2018

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Humoral immune response to flagellin requires T cells and activation of innate immunity

21 January 2018

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Isolation of flagellated bacteria implicated in Crohn's disease.

21 January 2018

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Elevated flagellin-specific immunoglobulins in Crohn's disease.

21 January 2018

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Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine.

21 January 2018

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Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium

21 January 2018

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Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.

21 January 2018

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Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocol

21 January 2018

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Flagellin suppresses epithelial apoptosis and limits disease during enteric infection

21 January 2018

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Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease

21 January 2018

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Crohn's disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin.

21 January 2018

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Flagellin treatment protects against chemicals, bacteria, viruses, and radiation.

21 January 2018

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Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide

21 January 2018

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Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota

21 January 2018

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The genetics and immunopathogenesis of inflammatory bowel disease

21 January 2018

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NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.

21 January 2018

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Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.

21 January 2018

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Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis

21 January 2018

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Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.

21 January 2018

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Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease

21 January 2018

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IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin

21 January 2018

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Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IBD.20734

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19 August 2017

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