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The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.
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3857201
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29 February 2020
title
The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex
(English)
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PMC publication ID
3857201
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29 February 2020
author
Rafael Arrojo e Drigo
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1
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Europe PubMed Central
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3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
Péter Egri
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2
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Europe PubMed Central
PMC publication ID
3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
Antonio Bianco
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5
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3857201
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29 February 2020
author name string
Sungro Jo
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3
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3857201
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29 February 2020
Balázs Gereben
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4
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Europe PubMed Central
PMC publication ID
3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
publication date
6 November 2013
1 reference
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Europe PubMed Central
PMC publication ID
3857201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
published in
Molecular Endocrinology
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PMC publication ID
3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
volume
27
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Europe PubMed Central
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3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
issue
12
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Europe PubMed Central
PMC publication ID
3857201
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
page(s)
2105-2115
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Europe PubMed Central
PMC publication ID
3857201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
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The mammalian endoplasmic reticulum-associated degradation system
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6 September 2017
Cleaning up: ER-associated degradation to the rescue
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6 September 2017
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
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6 September 2017
The ubiquitin code
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6 September 2017
Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
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6 September 2017
The Cdc48 machine in endoplasmic reticulum associated protein degradation
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6 September 2017
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
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6 September 2017
Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
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6 September 2017
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
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6 September 2017
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
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6 September 2017
Breaking the chains: structure and function of the deubiquitinases
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One step at a time: endoplasmic reticulum-associated degradation
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6 September 2017
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
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6 September 2017
Inhibition of p97-dependent protein degradation by Eeyarestatin I
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6 September 2017
Proteasome-independent functions of ubiquitin in endocytosis and signaling
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6 September 2017
Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
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6 September 2017
The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane
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PubMed Central
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6 September 2017
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
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6 September 2017
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin
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6 September 2017
Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
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PubMed Central
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6 September 2017
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
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PubMed Central
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6 September 2017
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
6 September 2017
Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
6 September 2017
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
6 September 2017
ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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6 September 2017
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
6 September 2017
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
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14 September 2017
Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
14 September 2017
Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
14 September 2017
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
28 September 2017
Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
28 September 2017
A ratiometric expressible FRET sensor for phosphoinositides displays a signal change in highly dynamic membrane structures in fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
26 June 2018
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3857201
retrieved
26 June 2018
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24196352
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24196352
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1210/ME.2013-1281
1 reference
stated in
Europe PubMed Central
PMC publication ID
3857201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PMC publication ID
3857201
1 reference
stated in
Europe PubMed Central
PMC publication ID
3857201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PubMed publication ID
24196352
1 reference
stated in
Europe PubMed Central
PMC publication ID
3857201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196352%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
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