(Q37386626)

20 August 2017

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title

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (English)

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20 August 2017

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3

Donald E Ingber

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20 August 2017

Ning Wang

1

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PubMed ID

19197334

20 August 2017

Jessica D Tytell

series ordinal

2

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20 August 2017

1 January 2009

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Nature Reviews Molecular Cell Biology

20 August 2017

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20 August 2017

10

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20 August 2017

1

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20 August 2017

75-82

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https://scigraph.springernature.com/pub.10.1038/nrm2594

20 August 2017

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Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions

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Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

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Elementary mechanics of the endothelium of blood vessels

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Long-distance propagation of forces in a cell

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Cellular mechanotransduction: putting all the pieces together again

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Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds?

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Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition

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Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

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The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering?

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Mitochondrial displacements in response to nanomechanical forces

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Mapping mechanical strain of an endogenous cytoskeletal network in living endothelial cells

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Prestress mediates force propagation into the nucleus

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Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells

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Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device.

31 March 2020

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Rapid signal transduction in living cells is a unique feature of mechanotransduction.

31 March 2020

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Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells

31 March 2020

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Functional atlas of the integrin adhesome

31 March 2020

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Regulation of the association of alpha 6 beta 4 with vimentin intermediate filaments in endothelial cells.

31 March 2020

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Regulation of cadherin-mediated adhesion in morphogenesis

31 March 2020

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Lamin B constitutes an intermediate filament attachment site at the nuclear envelope

31 March 2020

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Two distinct attachment sites for vimentin along the plasma membrane and the nuclear envelope in avian erythrocytes: a basis for a vectorial assembly of intermediate filaments

31 March 2020

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Coupling of the nucleus and cytoplasm: role of the LINC complex

31 March 2020

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SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

31 March 2020

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The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope

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Here come the SUNs: a nucleocytoskeletal missing link

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Sun2 is a novel mammalian inner nuclear membrane protein

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Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation

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Functional association of Sun1 with nuclear pore complexes

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Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

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Lamins A and C but not lamin B1 regulate nuclear mechanics.

31 March 2020

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31 March 2020

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Interaction between emerin and nuclear lamins

31 March 2020

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A lamin B receptor in the nuclear envelope

31 March 2020

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Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro

31 March 2020

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Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy

31 March 2020

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An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.

31 March 2020

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A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane

31 March 2020

1 reference

Emerin interacts in vitro with the splicing-associated factor, YT521-B

31 March 2020

1 reference

Inner nuclear membrane proteins: functions and targeting

31 March 2020

1 reference

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

31 March 2020

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Intermediate filament-mediated stretch-induced changes in chromatin: a hypothesis for growth initiation in cardiac myocytes

31 March 2020

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Intermediate filaments and stress

31 March 2020

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Nuclear lamins, diseases and aging

31 March 2020

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Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold

31 March 2020

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Identifying functional neighborhoods within the cell nucleus: proximity analysis of early S-phase replicating chromatin domains to sites of transcription, RNA polymerase II, HP1gamma, matrin 3 and SAF-A.

31 March 2020

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Nuclear titin interacts with A- and B-type lamins in vitro and in vivo

31 March 2020

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The giant protein titin: a major player in myocardial mechanics, signaling, and disease

31 March 2020

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As functional nuclear actin comes into view, is it globular, filamentous, or both?

31 March 2020

1 reference

Nuclear myosin VI enhances RNA polymerase II-dependent transcription

31 March 2020

1 reference

Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription

31 March 2020

1 reference

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane

31 March 2020

1 reference

Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts

31 March 2020

1 reference

From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics.

31 March 2020

1 reference

Replication and transcription: shaping the landscape of the genome

31 March 2020

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Predicting three-dimensional genome structure from transcriptional activity.

31 March 2020

1 reference

Role of RUNX family members in transcriptional repression and gene silencing

31 March 2020

1 reference

Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer

31 March 2020

1 reference

The dynamic organization of gene-regulatory machinery in nuclear microenvironments

31 March 2020

1 reference

Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus

31 March 2020

1 reference

Nuclear ion channel activity is regulated by actin filaments

31 March 2020

1 reference

Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy

31 March 2020

1 reference

In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C.

31 March 2020

1 reference

Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors

31 March 2020

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Association of nuclear matrix antigens with exon-containing splicing complexes

31 March 2020

1 reference

The kinase domain of titin controls muscle gene expression and protein turnover

31 March 2020

1 reference

The permeability of the nuclear envelope in dividing and nondividing cell cultures

31 March 2020

1 reference

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

31 March 2020

1 reference

Role of nuclear size in cell growth initiation

31 March 2020

1 reference

The functional response of upstream DNA to dynamic supercoiling in vivo

31 March 2020

1 reference

The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression

31 March 2020

1 reference

A multi-modular tensegrity model of an actin stress fiber

31 March 2020

1 reference

Viscoelastic properties of vimentin compared with other filamentous biopolymer networks

31 March 2020

1 reference

Physical plasticity of the nucleus in stem cell differentiation

31 March 2020

1 reference

Actin and myosin I in the nucleus: what next?

31 March 2020

1 reference

Mechanotransduction in vascular physiology and atherogenesis

31 March 2020

1 reference

Neurosensory mechanotransduction

31 March 2020

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Mechanotransduction gone awry

31 March 2020

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Environmental sensing through focal adhesions

31 March 2020

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Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

31 March 2020

1 reference

12 December 2020

Cytoplasmic rheology of passive neutrophils

1 reference

12 December 2020

Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells

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12 December 2020

The architectural organization of nuclear metabolism

1 reference

12 December 2020

Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF

1 reference

12 December 2020

unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM2594

1 reference

20 August 2017

1 reference

PubMed ID

19197334