(Q37393703)

20 August 2017

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title

The T(reg)/Th17 cell balance: a new paradigm for autoimmunity (English)

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20 August 2017

Eli M Eisenstein

1

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20 August 2017

Calvin B Williams

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

1 May 2009

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20 August 2017

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20 August 2017

65

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20 August 2017

5 Pt 2

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20 August 2017

26R-31R

1 reference

https://scigraph.springernature.com/pub.10.1203/pdr.0b013e31819e76c7

20 August 2017

0 references

cites work

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Regulatory T cell development in the absence of functional Foxp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Role of regulatory T cells and FOXP3 in human diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

DNA methylation controls Foxp3 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Microbial lipopeptides induce the production of IL-17 in Th cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TH17 cells in development: an updated view of their molecular identity and genetic programming

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Induction and effector functions of T(H)17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Differentiation and function of Th17 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Th17: an effector CD4 T cell lineage with regulatory T cell ties

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Targeting the development and effector functions of TH17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E31819E76C7

10.1203/PDR.0B013E31819E76C7

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

20 August 2017

0 references

1 reference