(Q37397814)

20 August 2017

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. (English)

1 reference

cancer-associated fibroblast

20 August 2017

1 reference

1 reference

1 reference

12

Anita B Hjelmeland

1 reference

20 August 2017

5

Justin Lathia

1 reference

20 August 2017

14

Jeremy N Rich

1 reference

20 August 2017

Fiorenza Lotti

1

1 reference

20 August 2017

Awad M Jarrar

2

1 reference

20 August 2017

Rish K Pai

3

1 reference

20 August 2017

Masahiro Hitomi

4

1 reference

20 August 2017

Adam Mace

6

1 reference

20 August 2017

Gerald A Gantt

7

1 reference

20 August 2017

Kumar Sukhdeo

8

1 reference

20 August 2017

Jennifer DeVecchio

9

1 reference

20 August 2017

Amit Vasanji

10

1 reference

20 August 2017

Patrick Leahy

11

1 reference

20 August 2017

Matthew F Kalady

13

1 reference

20 August 2017

language of work or name

English

0 references

publication date

9 December 2013

1 reference

Journal of Experimental Medicine

20 August 2017

1 reference

20 August 2017

210

1 reference

20 August 2017

13

1 reference

20 August 2017

2851-2872

1 reference

describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3865474/fullTextXML

inferred from PubMed Central ID database lookup

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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A CXCL1 paracrine network links cancer chemoresistance and metastasis

6 September 2017

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Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling

6 September 2017

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

6 September 2017

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

6 September 2017

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Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance

6 September 2017

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Cancer stem cells: impact, heterogeneity, and uncertainty

6 September 2017

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Slug and Sox9 cooperatively determine the mammary stem cell state

6 September 2017

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Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

6 September 2017

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Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

6 September 2017

1 reference

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Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

6 September 2017

1 reference

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Stromal fibroblasts in digestive cancer

6 September 2017

1 reference

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

6 September 2017

1 reference

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DNA damage-mediated induction of a chemoresistant niche

6 September 2017

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Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

6 September 2017

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Targeted treatments in colorectal cancer: state of the art and future perspectives

6 September 2017

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The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer

6 September 2017

1 reference

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Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers

6 September 2017

1 reference

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Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer

6 September 2017

1 reference

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

6 September 2017

1 reference

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Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery

6 September 2017

1 reference

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Cancer stem cells from colorectal cancer-derived cell lines.

6 September 2017

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Cancer associated fibroblasts (CAFs) in tumor microenvironment

6 September 2017

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Molecular origins of cancer: Molecular basis of colorectal cancer

6 September 2017

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Transcriptional control of the inflammatory response

6 September 2017

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Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?

6 September 2017

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Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum

6 September 2017

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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

6 September 2017

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Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth

6 September 2017

1 reference

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Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer

6 September 2017

1 reference

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Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Crypt stem cells as the cells-of-origin of intestinal cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Cancer as an overhealing wound: an old hypothesis revisited

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Identification of stem cells in small intestine and colon by marker gene Lgr5

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Phenotypic characterization of human colorectal cancer stem cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Identification and expansion of human colon-cancer-initiating cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Molecular characterization of the tumor microenvironment in breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Role of myofibroblasts at the invasion front

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Mechanisms of myofibroblast activity and phenotypic modulation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

CD44 promotes resistance to apoptosis in human colon cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

The role of transforming growth factor beta 1 in the fibroblastic reaction associated with rat colorectal tumor development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Changes in the Secretory Profile of NSCLC-Associated Fibroblasts after Ablative Radiotherapy: Potential Impact on Angiogenesis and Tumor Growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Chemotherapeutic resistance: surviving stressful situations

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Alpha smooth muscle actin positive stromal cells in gastric carcinoma

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Role of IL-17A in the development of colitis-associated cancer.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

CD44 promotes resistance to apoptosis in murine colonic epithelium.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3865474

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

2 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131195

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131195

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131195

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131195

Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model

21 January 2018

1 reference

12 December 2020

Colon cancer stem cells

1 reference

12 December 2020

Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues

1 reference

12 December 2020

Heterogeneity of stromal fibroblasts in tumors

1 reference

12 December 2020

Identification of fibroblast heterogeneity in the tumor microenvironment

1 reference

12 December 2020

Significance of Lgr5(+ve) cancer stem cells in the colon and rectum

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20131195

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

24323355

1 reference