(Q37403124)

20 August 2017

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis (English)

1 reference

20 August 2017

0 references

1 reference

Paul Webster

6

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author name string

Olga A Mareninova

1

1 reference

20 August 2017

Kip Hermann

2

1 reference

20 August 2017

Samuel W French

3

1 reference

20 August 2017

Mark S O'Konski

4

1 reference

20 August 2017

Stephen J Pandol

5

1 reference

20 August 2017

Ann H Erickson

7

1 reference

20 August 2017

Nobuhiko Katunuma

8

1 reference

20 August 2017

Fred S Gorelick

9

1 reference

20 August 2017

Ilya Gukovsky

10

1 reference

20 August 2017

Anna S Gukovskaya

11

1 reference

20 August 2017

language of work or name

English

0 references

publication date

1 October 2009

1 reference

Journal of Clinical Investigation

20 August 2017

1 reference

20 August 2017

119

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20 August 2017

11

1 reference

20 August 2017

3340-3355

1 reference

describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2769194/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

6 September 2017

1 reference

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6 September 2017

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Autophagy fights disease through cellular self-digestion

6 September 2017

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Autophagy in the Pathogenesis of Disease

6 September 2017

1 reference

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

6 September 2017

1 reference

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Autophagosome formation: core machinery and adaptations

6 September 2017

1 reference

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Cysteine cathepsins: cellular roadmap to different functions

6 September 2017

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Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells

6 September 2017

1 reference

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Why does pancreatic overstimulation cause pancreatitis?

6 September 2017

1 reference

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Biochemical models of hereditary pancreatitis

6 September 2017

1 reference

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Inhibition of macroautophagy triggers apoptosis

6 September 2017

1 reference

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Vacuolar ATPase regulates zymogen activation in pancreatic acini

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Methods for monitoring autophagy

6 September 2017

1 reference

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

6 September 2017

1 reference

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At the acidic edge: emerging functions for lysosomal membrane proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Processing and activation of lysosomal proteinases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Disease model: LAMP-2 enlightens Danon disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Rab7: a key to lysosome biogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes

6 September 2017

1 reference

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Pancreatic acinar ultrastructure in human acute pancreatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Biosynthesis of lysosomal endopeptidases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Proteases and proteolysis in the lysosome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Subcellular fractionation of the pancreas

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, temperature, and proteolytic inhibitors

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Cell death in pancreatitis: caspases protect from necrotizing pancreatitis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Role of S-adenosylmethionine in two experimental models of pancreatitis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769194

Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis

2 September 2018

1 reference

12 December 2020

Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreas

1 reference

12 December 2020

Early events in acute pancreatitis

1 reference

12 December 2020

Alteration of membrane fusion as a cause of acute pancreatitis in the rat

1 reference

12 December 2020

The activation of trypsinogen by cathepsin B

1 reference

12 December 2020

Early events in acute pancreatitis

1 reference

12 December 2020

Diurnal variation in secretory components of the rat parotid gland

1 reference

12 December 2020

Regression of autophagic vacuoles in pancreatic acinar, seminal vesicle epithelial, and liver parenchymal cells: a comparative morphometric study of the effect of vinblastine and leupeptin followed by cycloheximide treatment

1 reference

12 December 2020

Human acute pancreatitis: a light and electron microscopic study

1 reference

12 December 2020

In vivo rat pancreatic acinar cell function during supramaximal stimulation with caerulein

1 reference

12 December 2020

Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis

1 reference

12 December 2020

A morphometric study of 24-hour variations in subcellular structures of the rat pancreatic acinar cell

1 reference

12 December 2020

Microwave-assisted processing and embedding for transmission electron microscopy

1 reference

12 December 2020

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis

1 reference

12 December 2020

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

1 reference

12 December 2020

Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis

1 reference

12 December 2020

Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini

1 reference

12 December 2020

Ultrastructure of early development of acute pancreatitis in the rat

1 reference

12 December 2020

Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophages

1 reference

12 December 2020

Lysosomal enzymes and pancreatitis

1 reference

12 December 2020

Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis

1 reference

12 December 2020

Lysosomal cysteine protease, cathepsin B, is targeted to lysosomes by the mannose 6-phosphate-independent pathway in rat hepatocytes: site-specific phosphorylation in oligosaccharides of the proregion

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI38674

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19805911

1 reference