(Q37409571)

English

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis

scientific article published on October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

schistosomiasis

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Stefanie Prast-Nielsen

object named as

Stefanie Prast-Nielsen

6

0 references

object named as

Hans F Luecke

4

0 references

object named as

Ajit Jadhav

7

0 references

14

object named as

Anton Simeonov

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Christopher P Austin

11

object named as

Christopher P Austin

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Ganesha Rai

1

1 reference

Europe PubMed Central

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20 August 2017

Ahmed A Sayed

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Wendy A Lea

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Harinath Chakrapani

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

William Leister

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Min Shen

9

1 reference

Europe PubMed Central

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20 August 2017

James Inglese

10

1 reference

Europe PubMed Central

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20 August 2017

Larry Keefer

12

1 reference

Europe PubMed Central

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20 August 2017

Elias S J Arnér

13

1 reference

Europe PubMed Central

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20 August 2017

David J Maloney

15

1 reference

Europe PubMed Central

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20 August 2017

David L Williams

16

1 reference

Europe PubMed Central

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20 August 2017

Craig J Thomas

17

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Europe PubMed Central

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20 August 2017

language of work or name

0 references

publication date

1 October 2009

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Europe PubMed Central

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20 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

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20 August 2017

52

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

6474-6483

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Helminth infections: the great neglected tropical diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

The unacknowledged impact of chronic schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Thioredoxin and related molecules--from biology to health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Innovative lead discovery strategies for tropical diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Schistosomiasis: challenges for control, treatment and drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Selenocysteine incorporation machinery and the role of selenoproteins in development and health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Nitric oxide: an antiparasitic molecule of invertebrates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Selenocysteine in proteins-properties and biotechnological use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Are Ca2+ channels targets of praziquantel action?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

NIH Molecular Libraries Initiative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

The prokaryotic selenoproteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Schistosomiasis control: keep taking the tablets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

The importance of glutathione in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Molecular bases for the anti-parasitic effect of NO (Review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Nitric oxide in parasitic infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

6 September 2017

Leishmania donovani: inhibition of phagosomal maturation is rescued by nitric oxide in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

14 September 2017

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

28 September 2017

Praziquantel, a new broad-spectrum antischistosomal agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

28 September 2017

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

26 June 2018

C-nitroso donors of nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

In vitro antihydatic action of IFN-gamma is dependent on the nitric oxide pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

A new furoxan NO-donor rabeprazole derivative and related compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

The biotin switch method for the detection of S-nitrosylated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

S-nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

An antiviral mechanism of nitric oxide: inhibition of a viral protease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

2 September 2018

Benznidazole and Chagas disease: can an old drug be the answer to an old problem?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

3 December 2018

Tumor Necrosis Factor (TNF) Receptor–1 (TNFp55) Signal Transduction and Macrophage‐Derived Soluble TNF Are Crucial for Nitric Oxide–MediatedTrypanosoma congolenseParasite Killing

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772170

3 December 2018

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the chemical properties of selenocysteine and selenocystine with their sulfur analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of cutaneous leishmaniasis with nitric-oxide donor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19761212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM901021K

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

0 references

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