(Q37409942)

20 August 2017

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy (English)

1 reference

20 August 2017

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Garry R. Buettner

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1

Claire M Doskey

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Visarut Buranasudja

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Brett A Wagner

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Justin G Wilkes

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Juan Du

5

1 reference

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4 June 2020

publication date

28 October 2016

1 reference

20 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

274-284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

4 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5106370/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

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Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture

9 September 2017

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Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

9 September 2017

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Role of labile iron in the toxicity of pharmacological ascorbate

9 September 2017

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Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer

9 September 2017

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Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects

9 September 2017

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Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis

9 September 2017

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Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study

9 September 2017

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Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific

9 September 2017

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Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

9 September 2017

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CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis

9 September 2017

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High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy

9 September 2017

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An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells

9 September 2017

1 reference

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Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation

9 September 2017

1 reference

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Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.

9 September 2017

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Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity

9 September 2017

1 reference

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Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo

9 September 2017

1 reference

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Mitochondrial DNA damage and its consequences for mitochondrial gene expression

9 September 2017

1 reference

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Ascorbic acid: chemistry, biology and the treatment of cancer.

9 September 2017

1 reference

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Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

9 September 2017

1 reference

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Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest.

9 September 2017

1 reference

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Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

9 September 2017

1 reference

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The rate of oxygen utilization by cells

9 September 2017

1 reference

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Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

9 September 2017

1 reference

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Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells

9 September 2017

1 reference

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Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer

9 September 2017

1 reference

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The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism

9 September 2017

1 reference

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How mitochondria produce reactive oxygen species

9 September 2017

1 reference

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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

9 September 2017

1 reference

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Reconciling the chemistry and biology of reactive oxygen species

9 September 2017

1 reference

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Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

9 September 2017

1 reference

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Cellular pharmacology of gemcitabine

9 September 2017

1 reference

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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues

9 September 2017

1 reference

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A metabolic model describing the H2O2 elimination by mammalian cells including H2O2 permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data

9 September 2017

1 reference

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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach

9 September 2017

1 reference

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Measuring gene-specific nucleotide excision repair in human cells using quantitative amplification of long targets from nanogram quantities of DNA.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Peroxisomes (microbodies and related particles)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Role of superoxide dismutase in cancer: a review

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Hydroperoxide metabolism in mammalian organs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

A study of the relative importance of the peroxiredoxin-, catalase-, and glutathione-dependent systems in neural peroxide metabolism

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

The separation and characterization of subcellular particles

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Alkylating DNA damage stimulates a regulated form of necrotic cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Tumor measurement in the nude mouse

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Kinetics of hydrogen peroxide elimination by human umbilical vein endothelial cells in culture.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Antioxidant enzyme levels in cancer

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Kinetic studies on the removal of extracellular hydrogen peroxide by cultured fibroblasts

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Heme occupancy of catalase in hemoglobin-free perfused rat liver and of isolated rat liver catalase

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Hydrogen peroxide metabolism and sensing in human erythrocytes: a validated kinetic model and reappraisal of the role of peroxiredoxin II.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5106370

ACTIVITY OF CATALASE IN THE RED CELL

2 September 2018

1 reference

12 December 2020

Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments

1 reference

12 December 2020

GLUTATHIONE PEROXIDASE: THE PRIMARY AGENT FOR THE ELIMINATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES

1 reference

12 December 2020

Metabolism of hydrogen peroxide in isolated hepatocytes: Relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2

1 reference

12 December 2020

STUDIES ON RAT LIVER CATALASE. I. COMBINED IMMUNOCHEMICAL AND ENZYMATIC DETERMINATION OF CATALASE IN LIVER CELL FRACTIONS

1 reference

12 December 2020

10.1016/J.REDOX.2016.10.010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27833040%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

27833040

1 reference