(Q37422773)

English

Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity

scientific article published on 17 June 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

0 references

multiple drug resistance

1 reference

based on heuristic

inferred from title

Alex Sparreboom

3

object named as

Alex Sparreboom

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

6

object named as

Sean Ekins

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Yu Fukuda

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Kazumasa Takenaka

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Satish B Cheepala

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Chung-Pu Wu

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Suresh V Ambudkar

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

John D Schuetz

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

publication date

17 June 2013

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Molecular Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

84

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

361-371

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides

1 reference

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23 August 2017

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

1 reference

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23 August 2017

Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition

1 reference

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23 August 2017

The rising challenge of non-AIDS-defining cancers in HIV-infected patients

1 reference

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23 August 2017

Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

1 reference

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23 August 2017

ABC transporters and their role in nucleoside and nucleotide drug resistance

1 reference

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23 August 2017

Use of antineoplastic agents in patients with cancer who have HIV/AIDS.

1 reference

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23 August 2017

Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir

1 reference

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23 August 2017

Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?

1 reference

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23 August 2017

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity

1 reference

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23 August 2017

Troubleshooting computational methods in drug discovery

1 reference

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23 August 2017

The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transporters

1 reference

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23 August 2017

Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery

1 reference

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23 August 2017

HMDB: a knowledgebase for the human metabolome

1 reference

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23 August 2017

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

23 August 2017

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

23 August 2017

Mechanism of active renal tubular efflux of tenofovir

1 reference

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23 August 2017

Treatment of acute lymphoblastic leukemia

1 reference

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23 August 2017

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

1 reference

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23 August 2017

HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

1 reference

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23 August 2017

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

1 reference

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23 August 2017

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

23 August 2017

KEGG: kyoto encyclopedia of genes and genomes

1 reference

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23 August 2017

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

23 August 2017

Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients

1 reference

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14 September 2017

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

1 reference

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14 September 2017

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

14 September 2017

Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing

1 reference

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28 September 2017

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

28 September 2017

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

1 reference

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28 September 2017

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1 reference

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28 September 2017

Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

28 September 2017

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

1 reference

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26 June 2018

Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

1 reference

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26 June 2018

HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

2 September 2018

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876819

2 September 2018

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein

1 reference

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2 September 2018

A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection

1 reference

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2 September 2018

Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/23775562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tenofovir disoproxil fumarate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23775562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer: the results of 20 years of follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/23775562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor Potential of Acyclic Nucleoside Phosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/23775562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.113.086967

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

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