(Q37426990)

English

Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

based on heuristic

inferred from title

author name string

Michael Emmett

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

publication date

14 November 2013

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Clinical Journal of the American Society of Nephrology

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

191-200

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

The pathogenesis of cystinosis: mechanisms beyond cystine accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

5-Oxoproline (pyroglutamic) acidosis associated with chronic acetaminophen use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Mechanisms of acetaminophen-induced liver necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Glutathione dysregulation and the etiology and progression of human diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Glutathione: overview of its protective roles, measurement, and biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Acetylcysteine for acetaminophen poisoning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Regulation of glutathione synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

The central role of glutathione in the pathophysiology of human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Profound metabolic acidosis and oxoprolinuria in an adult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Effect of acute paracetamol overdose on changes in serum and urine electrolytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Inborn errors in the metabolism of glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

The gamma-glutamyl cycle: a possible transport system for amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Inter-subject and ethnic differences in paracetamol metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Purification and catalytic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

23 August 2017

The excretion of 5-oxoproline in urine, as an index of glycine status, during normal pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

6 September 2017

New Aspects of Glutathione Metabolism and Translocation in Mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

6 September 2017

Glutathione Deficiency, Pyroglutamic Acidemia and Amino Acid Transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

6 September 2017

Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

14 September 2017

Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

26 June 2018

Partial reactions catalyzed by -glutamylcysteine synthetase and evidence for an activated glutamate intermediate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

26 June 2018

Pyroglutamic acidemia in an adult patient.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

26 June 2018

Severe anion gap metabolic acidosis from acetaminophen use secondary to 5-oxoproline (pyroglutamic acid) accumulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

5-Oxoprolinuria as a cause of high anion gap metabolic acidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

An unusual cause of high anion gap metabolic acidosis: pyroglutamic acidemia. A case report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Mind the gap! An unusual metabolic acidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Delayed onset of acute renal failure after significant paracetamol overdose: A case series

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Infants in Trinidad excrete more 5-L-oxoproline (L-pyroglutamic acid) in urine than infants in England: an environmental not ethnic difference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878708

2 September 2018

Induction of 5-oxoprolinuria in the rat following chronic feeding with N -acetyl 4-aminophenol (paracetamol)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term administration of toxic doses of paracetamol (acetaminophen) to rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on Matrigel and type 1 collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypophosphataemia and phosphaturia in paracetamol poisoning

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pyroglutamic acidemia associated with acetaminophen]

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An unusual cause of severe metabolic acidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamic acidemia: a cause of high anion gap metabolic acidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Madam, why are you so sour? Cause, diagnosis and complication of 5-oxoprolinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamic acidosis in a renal transplant patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamicaciduria from vigabatrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vigabatrin and urinary 5-oxoproline

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical pyroglutamic aciduria: possible role of paracetamol

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rare cause of high anion gap metabolic acidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24235282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2215/CJN.07730713

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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