(Q37428727)

20 August 2017

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title

Capturing adenylyl cyclases as potential drug targets (English)

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20 August 2017

Sandra Pierre

1

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20 August 2017

Thomas Eschenhagen

series ordinal

2

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20 August 2017

Gerd Geisslinger

series ordinal

3

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20 August 2017

Klaus Scholich

series ordinal

4

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20 August 2017

1 April 2009

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Nature Reviews Drug Discovery

20 August 2017

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20 August 2017

8

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20 August 2017

4

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20 August 2017

321-335

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https://scigraph.springernature.com/pub.10.1038/nrd2827

20 August 2017

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31 March 2020

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31 March 2020

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Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation

31 March 2020

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Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

31 March 2020

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Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline

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Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

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Ca2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: possible relation to type I adenylyl cyclase

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Alzheimer amyloid beta-peptide A-beta25-35 blocks adenylate cyclase-mediated forms of hippocampal long-term potentiation

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Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.

31 March 2020

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Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory

31 March 2020

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Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.

31 March 2020

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Distinct destructive signal pathways of neuronal death in Alzheimer's disease.

31 March 2020

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Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors.

31 March 2020

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Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.

31 March 2020

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Animal models of Alzheimer's disease and frontotemporal dementia

31 March 2020

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Survival of patients with a new diagnosis of heart failure: a population based study

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What is the role of beta-adrenergic signaling in heart failure?

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Adenylyl cyclase: a new target for heart failure therapeutics

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Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

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A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

31 March 2020

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Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.

31 March 2020

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New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy

31 March 2020

1 reference

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation

31 March 2020

1 reference

Adenylyl cyclase type V deletion increases basal left ventricular function and reduces left ventricular contractile responsiveness to beta-adrenergic stimulation

31 March 2020

1 reference

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress

31 March 2020

1 reference

Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration

31 March 2020

1 reference

The effects of trimetoquinol on the intact rabbit heart and myocardial adenylate cyclase activity: evidence for spare myocardial beta receptors

31 March 2020

1 reference

Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries

31 March 2020

1 reference

Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure

31 March 2020

1 reference

Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs

31 March 2020

1 reference

Decreased type VI adenylyl cyclase mRNA concentration and Mg(2+)-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn(2+)-dependent adenylyl cyclase activities in the left ventricle of rats with myoca

31 March 2020

1 reference

Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling

31 March 2020

1 reference

Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy

31 March 2020

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Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction

31 March 2020

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Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice

31 March 2020

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Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function

31 March 2020

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

31 March 2020

1 reference

Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice

31 March 2020

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31 March 2020

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Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase

31 March 2020

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Pharmacokinetics and a simulation model of colforsin daropate, new forskolin derivative inotropic vasodilator, in patients undergoing coronary artery bypass grafting.

31 March 2020

1 reference

Chronic direct stimulation of adenylyl cyclase induces cardiac desensitization to catecholamine and beta-adrenergic receptor downregulation in rabbits

31 March 2020

1 reference

Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine

31 March 2020

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31 March 2020

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31 March 2020

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Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle

31 March 2020

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An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation

31 March 2020

1 reference

Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.

31 March 2020

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Influence of colforsin daropate hydrochloride on internal mammary artery grafts

31 March 2020

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Effect of prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, on airway resistance after tracheal intubation.

31 March 2020

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Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma

31 March 2020

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Daily spermatozoal production and epididymal spermatozoal reserves of the human male

31 March 2020

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Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men.

31 March 2020

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Drug insight: Recent advances in male hormonal contraception.

31 March 2020

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Cyclic adenosine 3',5'monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility

31 March 2020

1 reference

Fertilizing Capacity of Spermatozoa deposited into the Fallopian Tubes

31 March 2020

1 reference

Involvement of a Na+/HCO-3 cotransporter in mouse sperm capacitation

31 March 2020

1 reference

Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility.

31 March 2020

1 reference

Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.

31 March 2020

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A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)

31 March 2020

1 reference

Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation

31 March 2020

1 reference

Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice

31 March 2020

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Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect

31 March 2020

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Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.

31 March 2020

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Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function

31 March 2020

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Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa

31 March 2020

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Specific expression of soluble adenylyl cyclase in male germ cells

31 March 2020

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Tyrosine phosphorylation of the a kinase anchoring protein 3 (AKAP3) and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonate

31 March 2020

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Bicarbonate-regulated Adenylyl Cyclase (sAC) Is a Sensor That Regulates pH-dependent V-ATPase Recycling

31 March 2020

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A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen

31 March 2020

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The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization

31 March 2020

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Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation

31 March 2020

1 reference

Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates.

31 March 2020

1 reference

Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP

31 March 2020

1 reference

The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition

31 March 2020

1 reference

Molecular basis for P-site inhibition of adenylyl cyclase

31 March 2020

1 reference

Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents

31 March 2020

1 reference

Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms

31 March 2020

1 reference

Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity

31 March 2020

1 reference

Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine

31 March 2020

1 reference

2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.

31 March 2020

1 reference

Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.

31 March 2020

1 reference

Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate

31 March 2020

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A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors

31 March 2020

1 reference

Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors

31 March 2020

1 reference

Molecular details of cAMP generation in mammalian cells: a tale of two systems

31 March 2020

1 reference

Tyrphostins are inhibitors of guanylyl and adenylyl cyclases

31 March 2020

1 reference

Structure-based development of novel adenylyl cyclase inhibitors

31 March 2020

1 reference

Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium

31 March 2020

1 reference

Differential identification and localization of adenylyl cyclase and glucose transporter in brain using iodinated derivatives of forskolin

31 March 2020

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Structure of the adenylyl cyclase catalytic core

31 March 2020

1 reference

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

31 March 2020

1 reference

Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.

31 March 2020

1 reference

Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin

31 March 2020

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Characterization of soluble forms of nonchimeric type V adenylyl cyclases

31 March 2020

1 reference

Functional analyses of type V adenylyl cyclase

31 March 2020

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Two-metal-Ion catalysis in adenylyl cyclase

31 March 2020

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The interactions of adenylate cyclases with P-site inhibitors

31 March 2020

1 reference

Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

31 March 2020

1 reference

Modeling of Galpha(s) and Galpha(i) regulation of human type V and VI adenylyl cyclase

31 March 2020

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Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

31 March 2020

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Identification of a Gialpha binding site on type V adenylyl cyclase

31 March 2020

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Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases

31 March 2020

2 references

31 March 2020

12 December 2020

Crystal structure of the guanylyl cyclase Cya2

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Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.

31 March 2020

1 reference

Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.

31 March 2020

1 reference

Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice

31 March 2020

1 reference

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase

31 March 2020

1 reference

Cloning and characterization of the human soluble adenylyl cyclase

31 March 2020

1 reference

Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.

31 March 2020

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Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

31 March 2020

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Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP

31 March 2020

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Immunodetection of adenylyl cyclase protein in tissues

31 March 2020

1 reference

Adenylyl cyclase isoforms in rat testis and spermatozoa from the cauda epididymidis.

31 March 2020

1 reference

Localization and differential expression of adenylyl cyclase messenger ribonucleic acids in rat adrenal gland determined by in situ hybridization

31 March 2020

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Localization of mRNAs encoding Ca2+-inhibitable adenylyl cyclases along the renal tubule. Functional consequences for regulation of the cAMP content

31 March 2020

1 reference

Adenylyl cyclase isoforms in the vestibular periphery of the rat

31 March 2020

1 reference

The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice.

31 March 2020

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Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.

31 March 2020

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Perinatal expression of adenylyl cyclase subtypes in rat brown adipose tissue

31 March 2020

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12 December 2020

Therapeutic benefit of PDE4 inhibitors in inflammatory diseases.

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12 December 2020

Adenylyl cyclase and G protein receptor kinase expression during development of heart failure.

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12 December 2020

Xamoterol in severe heart failure. The Xamoterol in Severe Heart Failure Study Group

1 reference

12 December 2020

Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle: implications for a new target of pharmacotherapy

1 reference

12 December 2020

Specific expression of soluble adenylyl cyclase in male germ cells

1 reference

12 December 2020

Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway

1 reference

12 December 2020

Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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12 December 2020

Identifiers

DOI

10.1038/NRD2827

1 reference

20 August 2017

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