(Q37431317)

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Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms

scientific article published on 09 September 2009

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7 February 2020

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms (English)

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7 February 2020

cystic fibrosis

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transmembrane protein

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4

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7 February 2020

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Karen Bernard

1

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7 February 2020

Wei Wang

2

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7 February 2020

Rajeshwar Narlawar

3

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7 February 2020

Kevin L Kirk

5

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7 February 2020

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9 September 2009

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7 February 2020

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12

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Journal of Biological Chemistry

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7 February 2020

284

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7 February 2020

45

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7 February 2020

30754-30765

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7 February 2020

describes a project that uses

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11 June 2022

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Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease

1 reference

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1 reference

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Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

1 reference

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Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease

1 reference

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Membrane-thinning effect of curcumin

1 reference

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23 August 2017

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781474

23 August 2017

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

1 reference

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23 August 2017

Dose escalation of a curcuminoid formulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781474

23 August 2017

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

1 reference

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23 August 2017

Actions of ultraviolet light on cellular structures.

1 reference

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23 August 2017

Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation

1 reference

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23 August 2017

Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction

1 reference

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23 August 2017

Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781474

23 August 2017

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

1 reference

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23 August 2017

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2

1 reference

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23 August 2017

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

1 reference

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6 September 2017

Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin

1 reference

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14 September 2017

Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains

1 reference

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14 September 2017

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

1 reference

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14 September 2017

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781474

14 September 2017

Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs

1 reference

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14 September 2017

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

1 reference

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14 September 2017

Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells

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Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

1 reference

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Molecular assembly of cystic fibrosis transmembrane conductance regulator in plasma membrane

1 reference

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Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1 reference

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Functions of the cystic fibrosis transmembrane conductance regulator protein

1 reference

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14 September 2017

Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator

1 reference

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A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules

1 reference

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Inhibition by singlet oxygen quenchers of oxidative damage to DNA produced in cultured cells by exposure to a quinolone antibiotic and ultraviolet A irradiation

1 reference

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

1 reference

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Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781474

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Cell protein cross-linking by erbstatin and related compounds.

1 reference

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26 June 2018

Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells.

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1 reference

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1 reference

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2 September 2018

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1 reference

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2 September 2018

Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.

1 reference

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1 reference

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19740743

12 December 2020

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inferred from PubMed ID database lookup

Cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19740743

12 December 2020

based on heuristic

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One- and two-photon photosensitized singlet oxygen production: characterization of aromatic ketones as sensitizer standards

1 reference

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inferred from PubMed ID database lookup

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19740743

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19740743

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based on heuristic

inferred from PubMed ID database lookup

Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A

1 reference

https://pubmed.ncbi.nlm.nih.gov/19740743

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.056010

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19740743%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PMC publication ID

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Europe PubMed Central

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7 February 2020

PubMed publication ID

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Europe PubMed Central

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7 February 2020

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