(Q37431412)

English

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop

scientific article published on 27 July 2009

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop (English)

1 reference

Europe PubMed Central

20 August 2017

amyotrophic lateral sclerosis

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author name string

Kathleen S Molnar

1

1 reference

Europe PubMed Central

20 August 2017

N Murat Karabacak

2

1 reference

Europe PubMed Central

20 August 2017

Joshua L Johnson

3

1 reference

Europe PubMed Central

20 August 2017

Qi Wang

4

1 reference

Europe PubMed Central

20 August 2017

Ashutosh Tiwari

5

1 reference

Europe PubMed Central

20 August 2017

Lawrence J Hayward

6

1 reference

Europe PubMed Central

20 August 2017

Stephen J Coales

7

1 reference

Europe PubMed Central

20 August 2017

Yoshitomo Hamuro

8

1 reference

Europe PubMed Central

20 August 2017

Jeffrey N Agar

9

1 reference

Europe PubMed Central

20 August 2017

language of work or name

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publication date

27 July 2009

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Europe PubMed Central

20 August 2017

number of pages

9

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inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

20 August 2017

284

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Europe PubMed Central

20 August 2017

45

1 reference

Europe PubMed Central

20 August 2017

30965-30973

1 reference

Europe PubMed Central

20 August 2017

Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival

1 reference

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Retrograde axonal transport and motor neuron disease

1 reference

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Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis

1 reference

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Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

1 reference

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Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS

1 reference

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How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

1 reference

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Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability

1 reference

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Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis

1 reference

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Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry

1 reference

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Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.

1 reference

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Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

1 reference

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

1 reference

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23 August 2017

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

1 reference

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Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry.

1 reference

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23 August 2017

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

1 reference

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Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding

1 reference

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Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

1 reference

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23 August 2017

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

1 reference

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23 August 2017

An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate

1 reference

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23 August 2017

Dynamic properties of the G93A mutant of copper-zinc superoxide dismutase as detected by NMR spectroscopy: implications for the pathology of familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

23 August 2017

Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: decreased stability of the apo state

1 reference

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23 August 2017

Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase

1 reference

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23 August 2017

Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS).

1 reference

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23 August 2017

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

23 August 2017

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

23 August 2017

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

1 reference

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Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation

1 reference

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23 August 2017

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

23 August 2017

Primary structure effects on peptide group hydrogen exchange

1 reference

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23 August 2017

Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

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Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

23 August 2017

Hydrogen exchange and structural dynamics of proteins and nucleic acids

2 references

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23 August 2017

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex

1 reference

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14 September 2017

Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

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Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

1 reference

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28 September 2017

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

1 reference

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Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis

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26 June 2018

Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice.

1 reference

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Kinetics of unfolding and folding from amide hydrogen exchange in native ubiquitin

1 reference

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26 June 2018

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

1 reference

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Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.

1 reference

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Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis

1 reference

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26 June 2018

Sensitive enzyme immunoassay for human Cu/Zn superoxide dismutase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

26 June 2018

Search of sequence databases with uninterpreted high-energy collision-induced dissociation spectra of peptides.

1 reference

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Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase

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Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution

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Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

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An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.

1 reference

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2 September 2018

Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

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Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins

1 reference

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Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase

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2 September 2018

Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site

1 reference

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2 September 2018

Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

2 September 2018

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement.

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2 September 2018

https://api.crossref.org/works/10.1074%2FJBC.M109.023945

21 January 2018

Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781497

2 October 2018

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

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2 October 2018

ALS, SOD and peroxynitrite

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.023945

21 January 2018

Identification of an apo-superoxide dismutase (Cu,Zn) pool in human lymphoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

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Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

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inferred from PubMed ID database lookup

Copper incorporation into superoxide dismutase in Menkes lymphoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

based on heuristic

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Cerebrospinal fluid levels of superoxide dismutases in neurological diseases detected by sensitive enzyme immunoassays

1 reference

https://pubmed.ncbi.nlm.nih.gov/19635794

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.023945

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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