(Q37441219)

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High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

scientific article published on September 2009

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6 February 2020

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells (English)

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6 February 2020

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6 February 2020

Gilberto Fronza

2

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6 February 2020

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6 February 2020

Paola Menichini

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6 February 2020

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Laura Ottaggio

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6 February 2020

Alberto Inga

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6 February 2020

Prema Iyer

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6 February 2020

Barry Gold

7

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6 February 2020

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1 September 2009

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6 February 2020

Mutation Research

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6 February 2020

671

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6 February 2020

1-2

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6 February 2020

58-66

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6 February 2020

Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo

1 reference

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23 August 2017

Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

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23 August 2017

Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

1 reference

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23 August 2017

Mechanisms of therapy-related carcinogenesis

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23 August 2017

Base excision repair intermediates are mutagenic in mammalian cells

1 reference

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23 August 2017

The biological effects of N3-methyladenine

1 reference

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23 August 2017

A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies

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23 August 2017

Targeting critical regions in genomic DNA with AT-specific anticancer drugs

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23 August 2017

HPRT mutations in humans: biomarkers for mechanistic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

Alu repeats and human disease

1 reference

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23 August 2017

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

Rate of depurination of native deoxyribonucleic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

HPRT: gene structure, expression, and mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

Automated DNA sequencing of the human HPRT locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

23 August 2017

Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin

1 reference

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14 September 2017

A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

28 September 2017

A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

28 September 2017

A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Duplication in the hypoxanthine phosphoribosyl-transferase gene caused by Alu-Alu recombination in a patient with Lesch Nyhan syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

The Chinese hamster HPRT gene: restriction map, sequence analysis, and multiplex PCR deletion screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Computer program for the analysis of mutational spectra: application to p53 mutations

1 reference

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2 September 2018

Molecular nature of spontaneous mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of two deletion events involving Alu-sequences, one novel base substitution and two tentative hotspot mutations in the hypoxanthine phosphoribosyltransferase (HPRT) gene in five patients with Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping large spontaneous deletion endpoints in the human HPRT gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MRFMMM.2009.08.013

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6 February 2020

PMC publication ID

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6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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6 February 2020

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