(Q36315585)

13 August 2017

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title

Mechanisms of therapy-related carcinogenesis (English)

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13 August 2017

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2

Lois B Travis

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13 August 2017

James M Allan

1

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PubMed ID

16294218

13 August 2017

language of work or name

English

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publication date

1 December 2005

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13 August 2017

Nature Reviews Cancer

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13 August 2017

5

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13 August 2017

943-955

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13 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc1749

13 August 2017

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cites work

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

1 reference

Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease

21 January 2018

1 reference

DNA adduct formation from tobacco-specific N-nitrosamines

21 January 2018

1 reference

Therapy-associated solid tumors

21 January 2018

1 reference

Genetic susceptibility to iatrogenic malignancy

31 March 2020

1 reference

Hodgkin's disease: complications of therapy and excess mortality

31 March 2020

1 reference

Long-term cause-specific mortality of patients treated for Hodgkin's disease

31 March 2020

1 reference

Lung cancer after treatment for Hodgkin's disease: focus on radiation effects

31 March 2020

1 reference

Frequent chromosomal translocations induced by DNA double-strand breaks

31 March 2020

1 reference

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

31 March 2020

1 reference

Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints

31 March 2020

1 reference

Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process

31 March 2020

1 reference

Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

31 March 2020

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DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

31 March 2020

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Secondary leukemias induced by topoisomerase-targeted drugs

31 March 2020

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Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints

31 March 2020

1 reference

Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.

31 March 2020

1 reference

31 March 2020

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

31 March 2020

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Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

31 March 2020

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MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

31 March 2020

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MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

31 March 2020

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Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

31 March 2020

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

31 March 2020

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The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

31 March 2020

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

31 March 2020

1 reference

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

31 March 2020

1 reference

Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.

31 March 2020

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Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides

31 March 2020

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Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals

31 March 2020

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Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation

31 March 2020

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Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype

31 March 2020

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High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome

31 March 2020

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Repopulating defect of mismatch repair–deficient hematopoietic stem cells

31 March 2020

1 reference

O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy

31 March 2020

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

31 March 2020

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DNA damage tolerance, mismatch repair and genome instability

31 March 2020

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Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

31 March 2020

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In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome

31 March 2020

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

31 March 2020

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Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.

31 March 2020

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Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells

31 March 2020

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Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations

31 March 2020

1 reference

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

31 March 2020

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Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine

31 March 2020

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Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells.

31 March 2020

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The mutator pathway is a feature of immunodeficiency-related lymphomas

31 March 2020

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High incidence of secondary brain tumours after radiotherapy and antimetabolites.

31 March 2020

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Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism

31 March 2020

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Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.

31 March 2020

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

31 March 2020

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Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line

31 March 2020

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Enrichment for DNA mismatch repair-deficient cells during treatment with cisplatin

31 March 2020

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A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

31 March 2020

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Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins.

31 March 2020

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The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients.

31 March 2020

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Risk of leukemia after platinum-based chemotherapy for ovarian cancer

31 March 2020

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Treatment-Associated Leukemia Following Testicular Cancer

31 March 2020

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Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

31 March 2020

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Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.

31 March 2020

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The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

31 March 2020

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Is mismatch repair really required for ionizing radiation-induced DNA damage signaling?

31 March 2020

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Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells

31 March 2020

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The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

31 March 2020

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The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells

31 March 2020

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Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor progno

31 March 2020

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Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells

31 March 2020

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Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.

31 March 2020

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Human MRE11 is inactivated in mismatch repair-deficient cancers

31 March 2020

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Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: a possible role in the aetiology of chemotherapy-induced leukaemia

31 March 2020

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Evidence of genetic instability in 3 Gy X-ray-induced mouse leukaemias and 3 Gy X-irradiated haemopoietic stem cells

31 March 2020

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Genetic instability in radiation-induced leukaemias: mouse models.

31 March 2020

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Genomic instability and bystander effects induced by high-LET radiation

31 March 2020

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Genomic instability and radiation

31 March 2020

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Genomic instability and bystander effects: a historical perspective

31 March 2020

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Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

31 March 2020

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

31 March 2020

1 reference

DNA alkylation and repair in the large bowel: animal and human studies

31 March 2020

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Role of DNA mismatch repair defects in the pathogenesis of human cancer

31 March 2020

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Leukemia following Hodgkin's disease

31 March 2020

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Leukemia following chemotherapy for ovarian cancer.

31 March 2020

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An E mu-BCL-2 transgene facilitates leukaemogenesis by ionizing radiation

31 March 2020

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p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

31 March 2020

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Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.

31 March 2020

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Breast Cancer Following Radiotherapy and Chemotherapy Among Young Women With Hodgkin Disease

31 March 2020

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Proliferation is necessary for both repair and mutation in transgenic mouse cells

31 March 2020

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Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts.

31 March 2020

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Second Malignant Neoplasms Among Long-Term Survivors of Hodgkin’s Disease: A Population-Based Evaluation Over 25 Years

31 March 2020

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Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease.

31 March 2020

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Establishment of a radiation- and estrogen-induced breast cancer model

31 March 2020

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Roles of radiotherapy and smoking in lung cancer following Hodgkin's disease.

31 March 2020

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Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin's lymphoma

31 March 2020

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Gastrointestinal cancer after treatment of Hodgkin's disease.

31 March 2020

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

31 March 2020

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31 March 2020

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Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors

31 March 2020

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Breast cancer after treatment of Hodgkin's disease.

31 March 2020

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Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment

31 March 2020

1 reference

Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1749

1 reference

13 August 2017

1 reference

PubMed ID

16294218