(Q46797440)

English

Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: a possible role in the aetiology of chemotherapy-induced leukaemia

scientific article published in March 2006

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: a possible role in the aetiology of chemotherapy-induced leukaemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

1 reference

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1 reference

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author name string

Worrillow LJ

1

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

Allan JM

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

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publication date

1 March 2006

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

25

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

12

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

1709-1720

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

Improved quantitative real-time RT-PCR for expression profiling of individual cells

1 reference

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The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A.

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A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.

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Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents

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Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.

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DNA repair: enzymatic mechanisms and relevance to drug response

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Therapy-related leukemia associated with alkylating agents

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Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

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Chromosomal stability and the DNA double-stranded break connection

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Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

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Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors

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Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells

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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

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Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.

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Mechanisms of tolerance to DNA damaging therapeutic drugs

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Human mismatch repair, drug-induced DNA damage, and secondary cancer.

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

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Hematopoietic commitment during embryonic stem cell differentiation in culture

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Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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The BRCA2 gene product functionally interacts with p53 and RAD51

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Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

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Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea.

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"Stemness": transcriptional profiling of embryonic and adult stem cells

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Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability

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High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome

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Therapy-related myeloid leukemia

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

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Regulation and mechanisms of mammalian double-strand break repair

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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Identifiers

10.1038/SJ.ONC.1209208

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16278672

ResearchGate publication ID

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