(Q37443866)

20 August 2017

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title

Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation (English)

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20 August 2017

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Gabriel A Rabinovich

1

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20 August 2017

Marta A Toscano

series ordinal

2

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20 August 2017

publication date

1 May 2009

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Nature Reviews Immunology

20 August 2017

published in

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20 August 2017

volume

9

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20 August 2017

issue

5

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20 August 2017

page(s)

338-352

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https://scigraph.springernature.com/pub.10.1038/nri2536

20 August 2017

exact match

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cites work

Mammalian glycosylation in immunity

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Protein-glycan interactions in the control of innate and adaptive immune responses

31 March 2020

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Functions of cell surface galectin-glycoprotein lattices

31 March 2020

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Galectins: structure, function and therapeutic potential

31 March 2020

1 reference

Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

31 March 2020

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

31 March 2020

1 reference

Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function

31 March 2020

1 reference

Oligosaccharide specificity of galectins: a search by frontal affinity chromatography.

31 March 2020

1 reference

Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens

31 March 2020

1 reference

Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells

31 March 2020

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Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease

31 March 2020

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Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses

31 March 2020

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Evidence of a role for galectin-1 in acute inflammation

31 March 2020

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What does the future hold for cell-based tolerogenic therapy?

31 March 2020

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Siglecs and their roles in the immune system

31 March 2020

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Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

31 March 2020

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T-cell activation through immunological synapses and kinapses

31 March 2020

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

31 March 2020

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N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells

31 March 2020

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Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis

31 March 2020

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Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling

31 March 2020

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Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction

31 March 2020

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Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.

31 March 2020

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Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes

31 March 2020

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Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes

31 March 2020

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Apoptosis of T cells mediated by galectin-1.

31 March 2020

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Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells

31 March 2020

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Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death

31 March 2020

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Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation

31 March 2020

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Galectin-8 induces apoptosis in the CD4(high)CD8(high) thymocyte subpopulation

31 March 2020

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Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle

31 March 2020

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Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways

31 March 2020

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Characterization of galectin-9-induced death of Jurkat T cells

31 March 2020

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Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes

31 March 2020

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The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death

31 March 2020

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CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans

31 March 2020

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Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death

31 March 2020

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Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

31 March 2020

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CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.

31 March 2020

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Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

31 March 2020

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Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

31 March 2020

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Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2.

31 March 2020

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Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1.

31 March 2020

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Galectin-1 Sensitizes Resting Human T Lymphocytes to Fas (CD95)-mediated Cell Death via Mitochondrial Hyperpolarization, Budding, and Fission

31 March 2020

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Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death

31 March 2020

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Galectin-1 supports survival of naive T cells without promoting cell proliferation

31 March 2020

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Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion

31 March 2020

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The thiol redox state of lymphoid organs is modified by immunization: role of different immune cell populations

31 March 2020

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Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation

31 March 2020

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Expression of galectin-3 modulates T-cell growth and apoptosis

31 March 2020

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Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis

31 March 2020

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Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice

31 March 2020

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Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma

31 March 2020

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Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts

31 March 2020

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Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

31 March 2020

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Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice

31 March 2020

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Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation.

31 March 2020

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Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection

31 March 2020

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A pivotal role for galectin-1 in fetomaternal tolerance

31 March 2020

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Amelioration of graft versus host disease by galectin-1.

31 March 2020

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Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.

31 March 2020

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Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis

31 March 2020

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Galectin-1 suppresses experimental colitis in mice

31 March 2020

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Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses.

31 March 2020

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Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1

31 March 2020

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Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma.

31 March 2020

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The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

31 March 2020

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Strongly enhanced IL-10 production using stable galectin-1 homodimers

31 March 2020

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Gene therapy with galectin-3 inhibits bronchial obstruction and inflammation in antigen-challenged rats through interleukin-5 gene downregulation

31 March 2020

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Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity

31 March 2020

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Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells

31 March 2020

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Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis.

31 March 2020

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Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering

31 March 2020

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Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation

31 March 2020

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Galectin-1 promotes immunoglobulin production during plasma cell differentiation

31 March 2020

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Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection.

31 March 2020

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Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells

31 March 2020

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T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins.

31 March 2020

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Immunosuppressive strategies that are mediated by tumor cells

31 March 2020

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Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins

31 March 2020

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Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

31 March 2020

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Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation.

31 March 2020

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Galectin-9 induces maturation of human monocyte-derived dendritic cells

31 March 2020

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

31 March 2020

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Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

31 March 2020

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Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix

31 March 2020

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Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells

31 March 2020

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Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages

31 March 2020

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A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway

31 March 2020

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Regulation of alternative macrophage activation by galectin-3.

31 March 2020

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Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages: modulation of microbicidal activity and survival

31 March 2020

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Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits

31 March 2020

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Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis

31 March 2020

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Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice

31 March 2020

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Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats

31 March 2020

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Suppression of autoimmune diabetes by soluble galectin-1

31 March 2020

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Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease?

31 March 2020

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Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration

31 March 2020

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Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking

31 March 2020

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T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1.

31 March 2020

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N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.

31 March 2020

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Galectin 3 and its binding protein in rheumatoid arthritis.

31 March 2020

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The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation

31 March 2020

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Galectin-3 Is an Amplifier of Inflammation in Atherosclerotic Plaque Progression Through Macrophage Activation And Monocyte Chemoattraction

31 March 2020

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Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro

31 March 2020

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Identification of autoantibodies associated with systemic lupus erythematosus

31 March 2020

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Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis

31 March 2020

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Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression

31 March 2020

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Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow.

31 March 2020

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Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma

31 March 2020

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Transcriptional regulation of galectin-10 (eosinophil Charcot-Leyden crystal protein): a GC box (-44 to -50) controls butyric acid induction of gene expression

31 March 2020

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Functional characterization of an eosinophil-specific galectin, ovine galectin-14.

31 March 2020

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Glycans in cancer and inflammation--potential for therapeutics and diagnostics

31 March 2020

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Galectins as modulators of tumour progression

31 March 2020

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Galectins in the tumor endothelium: opportunities for combined cancer therapy

31 March 2020

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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege

31 March 2020

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O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.

31 March 2020

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Galectin-1: a link between tumor hypoxia and tumor immune privilege

31 March 2020

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Tumor-associated galectin-3 modulates the function of tumor-reactive T cells

31 March 2020

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Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies

31 March 2020

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Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.

31 March 2020

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Anti-galectin compounds as potential anti-cancer drugs

31 March 2020

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Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation

31 March 2020

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Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase

31 March 2020

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Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9: possible implication of galectin-9 in interaction between L. major and host cells.

31 March 2020

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LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition

31 March 2020

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Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines

31 March 2020

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Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption

31 March 2020

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Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected

31 March 2020

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Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling.

31 March 2020

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Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans

31 March 2020

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Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

31 March 2020

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Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells.

31 March 2020

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Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes

31 March 2020

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Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes

31 March 2020

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12 December 2020

Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1

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12 December 2020

Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis

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12 December 2020

Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis

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12 December 2020

Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms

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12 December 2020

CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis

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12 December 2020

Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization

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12 December 2020

Roles of galectins in infection

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12 December 2020

Identifiers

DOI

10.1038/NRI2536

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Dimensions Publication ID

20 August 2017

1046628050

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