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The function of p27 KIP1 during tumor development.
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
review article
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Europe PubMed Central
title
The function of p27 KIP1 during tumor development
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
author
Sung Soo Kim
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
author name string
Jinhwa Lee
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
language of work or name
English
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inferred from title
publication date
1 November 2009
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Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
published in
Experimental and Molecular Medicine
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
volume
41
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
issue
11
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
page(s)
765-771
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
exact match
https://scigraph.springernature.com/pub.10.3858/emm.2009.41.11.102
0 references
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Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process
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Mirk regulates the exit of colon cancer cells from quiescence
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RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
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Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis
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Endocrine dysfunction in p27Kip1 deficient mice and susceptibility to Wnt-1 driven breast cancer
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Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model
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STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
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Lysophosphatidic acid induces cell migration through the selective activation of Akt1.
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Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis
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Post-translational regulation of the tumor suppressor p27(KIP1).
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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
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CDK inhibitors: cell cycle regulators and beyond
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23 August 2017
Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
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23 August 2017
TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy
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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype
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Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis
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PubMed Central
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23 August 2017
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
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PubMed Central
reference URL
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23 August 2017
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p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
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A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.
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Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation
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23 August 2017
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
Regulation of the cdk inhibitor p27 and its deregulation in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
CDK inhibitors: positive and negative regulators of G1-phase progression
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
23 August 2017
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
Animal cell cycles and their control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
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23 August 2017
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
14 September 2017
p27Kip1 modulates cell migration through the regulation of RhoA activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
28 September 2017
Translational control of p27Kip1 accumulation during the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
28 September 2017
Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
26 June 2018
p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
26 June 2018
Cyclin E-CDK2 is a regulator of p27Kip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
26 June 2018
The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
2 September 2018
Inhibition of p27Kip1 gene transcription by mitogens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
2 September 2018
Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788730
retrieved
2 September 2018
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19887899
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3858/EMM.2009.41.11.102
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
Dimensions Publication ID
1012818485
0 references
PMCID
2788730
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
PubMed ID
19887899
1 reference
stated in
Europe PubMed Central
PMCID
2788730
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19887899%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
ResearchGate publication ID
38065841
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