(Q37470595)

20 August 2017

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title

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis (English)

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20 August 2017

Porphyromonas gingivalis

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author

Lakshmi Wijeyewickrema

object named as

Lakshmi C Wijeyewickrema

series ordinal

2

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Robert N. Pike

object named as

Robert N Pike

series ordinal

3

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Rebecca M Fitzpatrick

series ordinal

1

object named as

Rebecca E Fitzpatrick

1 reference

PubMed ID

19416015

20 August 2017

language of work or name

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1 May 2009

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20 August 2017

17

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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20 August 2017

4

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20 August 2017

4

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20 August 2017

471-487

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The economics of periodontal diseases

20 August 2017

1 reference

Classifying periodontal diseases--a long-standing dilemma

21 January 2018

1 reference

Periodontal diagnoses and classification of periodontal diseases

21 January 2018

1 reference

Causation and pathogenesis of periodontal disease

21 January 2018

1 reference

The potential impact of periodontal disease on general health: a consensus view

21 January 2018

1 reference

The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis

21 January 2018

1 reference

Periodontal disease and mortality in type 2 diabetes

21 January 2018

1 reference

Poor periodontal health of the pregnant woman as a risk factor for low birth weight

21 January 2018

1 reference

Periodontal infection and preterm birth: results of a prospective study

21 January 2018

1 reference

Inter-relationships between rheumatoid arthritis and periodontal disease. A review.

21 January 2018

1 reference

Epidemiologic associations between periodontal disease and chronic obstructive pulmonary disease.

21 January 2018

1 reference

A review of the relationship between tooth loss, periodontal disease, and cancer

21 January 2018

1 reference

Subgingival microflora and periodontal disease

21 January 2018

1 reference

The role of dental plaque in gingivitis and periodontitis

21 January 2018

1 reference

Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis

21 January 2018

1 reference

21 January 2018

Periodontal diseases.

1 reference

Microbial complexes in subgingival plaque

21 January 2018

1 reference

Periodontal microbial ecology

21 January 2018

1 reference

Description of the subgingival microbiota of periodontally untreated Mexican subjects: chronic periodontitis and periodontal health.

21 January 2018

1 reference

Subgingival microbiota of chilean patients with chronic periodontitis.

21 January 2018

1 reference

Microbial etiological agents of destructive periodontal diseases

21 January 2018

1 reference

Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease: introduction

21 January 2018

1 reference

The porphyrin pigmentation of subspecies of Bacteroides melaninogenicus

21 January 2018

1 reference

Regulation of hemin and iron transport in Porphyromonas gingivalis.

21 January 2018

1 reference

Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis

21 January 2018

1 reference

Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83

21 January 2018

1 reference

Subgingival colonization by Porphyromonas gingivalis

21 January 2018

1 reference

In or out: the invasiveness of oral bacteria

21 January 2018

1 reference

Molecular interaction of Porphyromonas gingivalis with host cells: implication for the microbial pathogenesis of periodontal disease

21 January 2018

1 reference

Virulence factors of Porphyromonas gingivalis.

21 January 2018

1 reference

Antigens of bacteria associated with periodontitis.

21 January 2018

1 reference

Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire

21 January 2018

1 reference

Role of bacterial proteinases in matrix destruction and modulation of host responses

21 January 2018

1 reference

Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes

21 January 2018

1 reference

Cysteine proteases of Porphyromonas gingivalis

21 January 2018

1 reference

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

21 January 2018

1 reference

Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis

21 January 2018

1 reference

Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence.

21 January 2018

1 reference

Involvement of a lysine-specific cysteine proteinase in hemoglobin adsorption and heme accumulation by Porphyromonas gingivalis

21 January 2018

1 reference

Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model

21 January 2018

1 reference

Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis

21 January 2018

1 reference

The biphasic virulence activities of gingipains: activation and inactivation of host proteins

21 January 2018

1 reference

Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway

21 January 2018

1 reference

Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis

21 January 2018

1 reference

The role of gingipains in the pathogenesis of periodontal disease

21 January 2018

1 reference

Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin

21 January 2018

1 reference

Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis

21 January 2018

1 reference

Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy

21 January 2018

1 reference

Activation and novel processing of matrix metalloproteinases by a thiol-proteinase from the oral anaerobe Porphyromonas gingivalis.

21 January 2018

1 reference

Activation of human matrix metalloproteinase 2 by gingival crevicular fluid and Porphyromonas gingivalis

21 January 2018

1 reference

The periodontopathogen Porphyromonas gingivalis binds iron protoporphyrin IX in the mu-oxo dimeric form: an oxidative buffer and possible pathogenic mechanism

21 January 2018

1 reference

The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway

21 January 2018

1 reference

Cloning and expression of a Porphyromonas gingivalis gene for protoporphyrinogen oxidase by complementation of a hemG mutant of Escherichia coli

21 January 2018

1 reference

Hemoglobin hydrolysis and heme acquisition by Porphyromonas gingivalis

21 January 2018

1 reference

Protease-activated receptors: contribution to physiology and disease

21 January 2018

1 reference

Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

21 January 2018

1 reference

Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion

21 January 2018

1 reference

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity

21 January 2018

1 reference

Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture

21 January 2018

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Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling

21 January 2018

1 reference

Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells

21 January 2018

1 reference

Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection

21 January 2018

1 reference

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

21 January 2018

1 reference

Gingipains of Porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99.

21 January 2018

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Gingipains in the culture supernatant of Porphyromonas gingivalis cleave CD4 and CD8 on human T cells

21 January 2018

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Binding of Porphyromonas gingivalis gingipains to human CD4(+) T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression

21 January 2018

1 reference

Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis

21 January 2018

1 reference

Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population.

21 January 2018

1 reference

Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion

21 January 2018

1 reference

Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation

21 January 2018

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Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis

21 January 2018

1 reference

Hydrolysis of interleukin-12 by Porphyromonas gingivalis major cysteine proteinases may affect local gamma interferon accumulation and the Th1 or Th2 T-cell phenotype in periodontitis

21 January 2018

1 reference

Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

21 January 2018

1 reference

Protease-active extracellular protein preparations from Porphyromonas gingivalis W83 induce N-cadherin proteolysis, loss of cell adhesion, and apoptosis in human epithelial cells

21 January 2018

1 reference

Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells

21 January 2018

1 reference

Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis

21 January 2018

1 reference

Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein

21 January 2018

1 reference

Domain-specific rearrangement between the two Arg-gingipain-encoding genes in Porphyromonas gingivalis: possible involvement of nonreciprocal recombination.

21 January 2018

1 reference

The prpR1 and prR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes.

21 January 2018

1 reference

Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.

21 January 2018

1 reference

Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis

21 January 2018

1 reference

Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine proteinase (Arg-gingipain).

21 January 2018

1 reference

Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases

21 January 2018

1 reference

Characterization of a Porphyromonas gingivalis gene prtK that encodes a lysine-specific cysteine proteinase and three sequence-related adhesins.

21 January 2018

1 reference

Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes.

21 January 2018

1 reference

A cell-associated protein complex of Porphyromonas gingivalis W50 composed of Arg- and Lys-specific cysteine proteinases and adhesins.

21 January 2018

1 reference

Structural characterization of argingipain, a novel arginine-specific cysteine proteinase as a major periodontal pathogenic factor from Porphyromonas gingivalis.

21 January 2018

1 reference

Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor

21 January 2018

1 reference

The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis

21 January 2018

1 reference

Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria?

21 January 2018

1 reference

Glycosylation of the Arg-gingipains of Porphyromonas gingivalis and comparison with glycoconjugate structure and synthesis in other bacteria

21 January 2018

1 reference

The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83.

21 January 2018

1 reference

Inactivation of vimF, a putative glycosyltransferase gene downstream of vimE, alters glycosylation and activation of the gingipains in Porphyromonas gingivalis W83.

21 January 2018

1 reference

Altered gingipain maturation in vimA- and vimE-defective isogenic mutants of Porphyromonas gingivalis

21 January 2018

1 reference

A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems

21 January 2018

1 reference

Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold

21 January 2018

1 reference

Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis

21 January 2018

1 reference

Type II secretion: a protein secretion system for all seasons

21 January 2018

1 reference

Getting out: protein traffic in prokaryotes

21 January 2018

1 reference

The Tla protein of Porphyromonas gingivalis W50: a homolog of the RI protease precursor (PrpRI) is an outer membrane receptor required for growth on low levels of hemin

21 January 2018

1 reference

Porphyromonas gingivalis gingipains and adhesion to epithelial cells

21 January 2018

1 reference

Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia

21 January 2018

1 reference

Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells

21 January 2018

1 reference

An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss

21 January 2018

1 reference

Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells

21 January 2018

1 reference

Determination and characterization of the hemagglutinin-associated short motifs found in Porphyromonas gingivalis multiple gene products

21 January 2018

1 reference

RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model

21 January 2018

1 reference

Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides

21 January 2018

1 reference

Bacterial proteins binding to the mammalian extracellular matrix

21 January 2018

1 reference

MSCRAMM-mediated adherence of microorganisms to host tissues.

21 January 2018

1 reference

Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide

21 January 2018

1 reference

Periodontal infection as a possible risk factor for preterm low birth weight

21 January 2018

1 reference

Periodontal status of diabetics compared with nondiabetics: a meta-analysis

21 January 2018

1 reference

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.09.18

1 reference

20 August 2017

1 reference

PubMed ID

19416015