(Q37480847)

20 August 2017

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title

Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes (English)

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20 August 2017

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Richard J Cenedella

1

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20 August 2017

publication date

14 May 2009

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20 August 2017

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20 August 2017

volume

44

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20 August 2017

issue

6

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20 August 2017

page(s)

477-487

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Progesterone blocks cholesterol translocation from lysosomes

20 August 2017

cites work

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12 December 2020

Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells

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12 December 2020

Intracellular cholesterol transport

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12 December 2020

Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature

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12 December 2020

Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A

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12 December 2020

Autophagy--a basic mechanism and a potential role for neurodegeneration.

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12 December 2020

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease

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12 December 2020

Cataracts in Patients Treated with Triparanol

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12 December 2020

Neuronal cell death caused by inhibition of intracellular cholesterol trafficking is caspase dependent and associated with activation of the mitochondrial apoptosis pathway

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12 December 2020

Studies on the mechanism of the epileptiform activity induced by U18666A. II. Concentration, half-life and distribution of radiolabeled U18666A in the brain.

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12 December 2020

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons

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12 December 2020

Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions

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12 December 2020

ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity

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12 December 2020

Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane

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12 December 2020

Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons

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12 December 2020

Dual roles for cholesterol in mammalian cells

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12 December 2020

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols

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12 December 2020

Circulation of cholesterol between lysosomes and the plasma membrane

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12 December 2020

Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis

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12 December 2020

Characterization of Chinese hamster ovary cells that are resistant to 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism

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12 December 2020

Late endosome motility depends on lipids via the small GTPase Rab7.

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12 December 2020

Cholesterol modulates the membrane binding and intracellular distribution of annexin 6.

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12 December 2020

Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells

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12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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12 December 2020

Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport

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12 December 2020

Cholesterol and lipid peroxidation in 3 beta-(2-diethylaminoethoxy)- androst-5-en-17-oneHCl (U18666A) induced cataractogenesis in rats

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12 December 2020

Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Regional distribution of lipids and phospholipase A2 activity in normal and cataractous rat lens

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12 December 2020

Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor

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12 December 2020

GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures

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12 December 2020

Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.

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12 December 2020

Cholesterol and cataracts

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12 December 2020

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network

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12 December 2020

U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases

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12 December 2020

Serotonin depletion attenuates AY-9944-mediated atypical absence seizures.

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12 December 2020

Niemann-Pick disease type C

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12 December 2020

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action

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12 December 2020

A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.

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12 December 2020

Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.

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12 December 2020

Effects of 3 beta-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures

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12 December 2020

Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin

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12 December 2020

The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model.

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12 December 2020

Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: microarray and proteomics analyses in cultured murine cortical neurons

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12 December 2020

Inhibition of cholesterol biosynthesis in the rat by 3 beta-(2-diethylaminoethoxy) androst5-en-17-one hydrochloride

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12 December 2020

[Relation between chemical constitution and biological activity; new vasodilators and curare-simulants derived from sex hormones]

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12 December 2020

A model of atypical absence seizures: EEG, pharmacology, and developmental characterization

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12 December 2020

Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy

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12 December 2020

Pharmacological inhibition of the intracellular transport of low-density lipoprotein-derived cholesterol in Chinese hamster ovary cells

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12 December 2020

Electrocorticogram and behavioral correlates during the development of chronic cobalt experimental epilepsy in the rat.

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12 December 2020

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

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12 December 2020

Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29

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12 December 2020

Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat.

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12 December 2020

Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps

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12 December 2020

Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in HeLa cells

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12 December 2020

Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments: evidence for early endosome-to-TGN trafficking of MPR300.

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12 December 2020

Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice

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12 December 2020

Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats

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12 December 2020

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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12 December 2020

Retinal structure and function in an animal model that replicates the biochemical hallmarks of desmosterolosis

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12 December 2020

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one

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12 December 2020

Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis

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12 December 2020

Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase

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12 December 2020

Cataract Formation After Triparanol Therapy

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12 December 2020

5-HT2 modulation of AY-9944 induced atypical absence seizures

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12 December 2020

The fate of cholesterol exiting lysosomes

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12 December 2020

Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

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12 December 2020

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons

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12 December 2020

Anti-bis(monoacylglycero)phosphate antibody accumulates acetylated LDL-derived cholesterol in cultured macrophages

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12 December 2020

Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition

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12 December 2020

Intracellular cholesterol trafficking: role of the NPC1 protein

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12 December 2020

Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death

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12 December 2020

Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies

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12 December 2020

Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts

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12 December 2020

Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol

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12 December 2020

In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules

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12 December 2020

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

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12 December 2020

Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol

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12 December 2020

Direct evidence for immiscible cholesterol domains in human ocular lens fiber cell plasma membranes

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12 December 2020

Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles

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12 December 2020

Brain sterols in the AY-9944 rat model of atypical absence seizures.

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12 December 2020

Hormonal regulation of atypical absence seizures.

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12 December 2020

Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism

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12 December 2020

The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein

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12 December 2020

Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments

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12 December 2020

Mechanism of cataract production by 3-β(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: An inhibitor of cholesterol biosynthesis

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12 December 2020

Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model

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12 December 2020

Pharmacological analysis of sterol delta8-delta7 isomerase proteins with [3H]ifenprodil

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12 December 2020

NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.

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12 December 2020

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

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12 December 2020

Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

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12 December 2020

Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment

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12 December 2020

Evidence for distinct cholesterol domains in fiber cell membranes from cataractous human lenses

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12 December 2020

Cerebral Cortical Cholesterol Changes in Cobalt-Induced Epilepsy

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12 December 2020

A chronic model of atypical absence seizures: studies of developmental and gender sensitivity

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12 December 2020

Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts.

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12 December 2020

Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944

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12 December 2020

Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease

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12 December 2020

DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis

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12 December 2020

Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

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12 December 2020

Learning and memory impairment in rats with chronic atypical absence seizures.

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12 December 2020

U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells

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12 December 2020

Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport

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12 December 2020

Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells.

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12 December 2020

LM cell growth and membrane lipid adaptation to sterol structure

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12 December 2020

Refractory atypical absence seizures in rat: a two hit model

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12 December 2020

An ultrastructural analysis of plasma membrane in the U18666A cataract

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12 December 2020

Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole. A role for cytochrome P-450 in the regulation of HMG-CoA reductase in rat int

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12 December 2020

10.1007/S11745-009-3305-7

Identifiers

DOI

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20 August 2017

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