(Q37482035)

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Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

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Europe PubMed Central

20 August 2017

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer (English)

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Europe PubMed Central

20 August 2017

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Sanjeev Gumber

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Marit J. van Gils

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Colin Havenar-Daughton

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Dennis R. Burton

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Rogier W Sanders

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Alba Torrents de la Peña

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Matthias Pauthner

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Samantha M Reiss

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Samantha M Reiss

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Jennifer S Wood

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Sandy L Rosales

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Michela Locci

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Khoa M Le

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Ata Ur Rasheed Mohammed

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Jessica Huang

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AnaPatricia Garcia

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Grégory Seumois

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Guido Silvestri

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publication date

1 November 2016

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2195-2209

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20 August 2017

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

1 reference

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Activin A programs the differentiation of human TFH cells

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A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

1 reference

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HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

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Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

HIV-Host Interactions: Implications for Vaccine Design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Visualizing antibody affinity maturation in germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

CXCL13 is a plasma biomarker of germinal center activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Antibody responses to envelope glycoproteins in HIV-1 infection

1 reference

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Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization

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Animal models in HIV-1 protection and therapy

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Class-switched memory B cells remodel BCRs within secondary germinal centers

1 reference

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HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

1 reference

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23 August 2017

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

1 reference

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Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

23 August 2017

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

1 reference

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Antibodies in HIV-1 vaccine development and therapy

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IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans

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Broadly neutralizing antiviral antibodies

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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

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Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

1 reference

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CD4 T follicular helper cell dynamics during SIV infection

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Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

1 reference

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Germinal centers

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Broad neutralization coverage of HIV by multiple highly potent antibodies

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A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center

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Follicular helper CD4 T cells (TFH)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5142765

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Different B cell populations mediate early and late memory during an endogenous immune response

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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

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Correlates of protection induced by vaccination

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The role of antibodies in HIV vaccines

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Fine-needle aspiration (FNA) biopsy: historical aspects.

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

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Immunogen design to focus the B-cell repertoire

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Clinical experience with hepatitis B vaccines

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Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

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A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

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Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

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Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

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Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

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Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection

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Fine-Needle Aspiration Biopsy of the Lymph Node: A Novel Tool for the Monitoring of Immune Responses after Skin Antigen Delivery.

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Serial study of lymph node cell subsets using fine needle aspiration in pigtail macaques.

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Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

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A Phase II Study of Two HIV Type 1 Envelope Vaccines, Comparing Their Immunogenicity in Populations at Risk for Acquiring HIV Type 1 Infection

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QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immmunization in humans

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Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy: an analysis of 2,418 cases

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Identifiers

10.1016/J.CELREP.2016.10.085

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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