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EphA2 is a functional receptor for the growth factor progranulin.
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Europe PubMed Central
PMC publication ID
5146997
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
title
EphA2 is a functional receptor for the growth factor progranulin
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
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Simone Buraschi
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2
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Europe PubMed Central
PMC publication ID
5146997
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Catherine Sharpe
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4
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Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Elizabeth Natkanski
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5
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Europe PubMed Central
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5146997
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Liliana Schaefer
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6
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5146997
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28 March 2020
Andrea Morrione
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7
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Europe PubMed Central
PMC publication ID
5146997
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Renato V. Iozzo
series ordinal
8
object named as
Renato V Iozzo
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Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
author name string
Thomas Neill
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1
1 reference
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Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Atul Goyal
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3
1 reference
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Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
language of work or name
English
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publication date
30 November 2016
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Europe PubMed Central
PMC publication ID
5146997
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retrieved
28 March 2020
published in
Journal of Cell Biology
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Europe PubMed Central
PMC publication ID
5146997
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retrieved
28 March 2020
volume
215
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Europe PubMed Central
PMC publication ID
5146997
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
page(s)
687-703
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
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11 June 2022
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Europe PubMed Central
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11 June 2022
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Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior
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Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.
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Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment
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EphA2 and Src regulate equatorial cell morphogenesis during lens development
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Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model
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Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells
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Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase
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Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
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A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.
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Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
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Progranulin regulates neuronal outgrowth independent of sortilin
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Human cataract mutations in EPHA2 SAM domain alter receptor stability and function
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The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
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23 August 2017
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Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
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23 August 2017
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
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Protein-binding assays in biological liquids using microscale thermophoresis
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Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis.
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23 August 2017
Cell signaling by receptor tyrosine kinases
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23 August 2017
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
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23 August 2017
The granulin gene family: from cancer to dementia
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23 August 2017
EPHA2 is associated with age-related cortical cataract in mice and humans
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23 August 2017
Decorin is a novel antagonistic ligand of the Met receptor
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23 August 2017
Proepithelin is an autocrine growth factor for bladder cancer
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23 August 2017
EphA2 as a promoter of melanoma tumorigenicity
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23 August 2017
Towards understanding the neuronal ceroid lipofuscinoses.
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23 August 2017
Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.
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23 August 2017
The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting
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23 August 2017
Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists
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23 August 2017
Diverse cell signaling events modulated by perlecan.
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23 August 2017
Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor
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23 August 2017
Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro
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23 August 2017
A central function for perlecan in skeletal muscle and cardiovascular development
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23 August 2017
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
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23 August 2017
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
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23 August 2017
Loss of progranulin function in frontotemporal lobar degeneration
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23 August 2017
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
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23 August 2017
Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation
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23 August 2017
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
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PubMed Central
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23 August 2017
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
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23 August 2017
Basement membrane proteoglycans: from cellar to ceiling
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23 August 2017
Eph receptor tyrosine kinases in angiogenesis: from development to disease.
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23 August 2017
Eph receptors in the adult brain
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23 August 2017
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
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PubMed Central
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23 August 2017
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth
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23 August 2017
Mechanisms and functions of Eph and ephrin signalling
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retrieved
23 August 2017
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
23 August 2017
Structural and functional analysis of a promoter of the human granulin/epithelin gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
23 August 2017
Physiological role of epidermal growth factor on adipose tissue development in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
23 August 2017
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
23 August 2017
New discovery rarely runs smooth: an update on progranulin/TNFR interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
6 September 2017
JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
6 September 2017
Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
6 September 2017
EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
6 September 2017
Structure, function, and mechanism of progranulin; the brain and beyond
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
6 September 2017
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
14 September 2017
EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
14 September 2017
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
14 September 2017
Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
14 September 2017
Progranulin is a mediator of the wound response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
14 September 2017
Biological activities and signaling pathways of the granulin/epithelin precursor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
28 September 2017
Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
28 September 2017
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
26 June 2018
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
26 June 2018
PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
Quantifying spatial correlations of fluorescent markers using enhanced background reduction with protein proximity index and correlation coefficient estimations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5146997
retrieved
2 September 2018
Progranulin genetic variability contributes to amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1083%2FJCB.201603079
retrieved
21 January 2018
Biochemical analysis of the epithelin receptor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27903606
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27903606
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27903606
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1083/JCB.201603079
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
PMC publication ID
5146997
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
PubMed publication ID
27903606
1 reference
stated in
Europe PubMed Central
PMC publication ID
5146997
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
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