(Q37523207)

20 August 2017

1 reference

title

Genetic prognostic and predictive markers in colorectal cancer (English)

1 reference

20 August 2017

1 reference

Charles Swanton

3

0 references

Ian Tomlinson

series ordinal

5

object named as

Ian Tomlinson

1 reference

20 August 2017

2

Elaine Johnstone

1 reference

20 August 2017

Axel Walther

1

1 reference

20 August 2017

Rachel Midgley

series ordinal

4

1 reference

20 August 2017

David Kerr

series ordinal

6

1 reference

20 August 2017

language of work or name

English

0 references

publication date

18 June 2009

1 reference

20 August 2017

published in

Nature Reviews Cancer

1 reference

20 August 2017

volume

9

1 reference

20 August 2017

issue

7

1 reference

20 August 2017

page(s)

489-499

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc2645

20 August 2017

exact match

0 references

cites work

Systemic treatment of colorectal cancer

1 reference

Capecitabine: have we got the dose right?

31 March 2020

1 reference

Evolution of nonsurgical therapy for colorectal cancer

31 March 2020

1 reference

Prognostic indicators of colon tumors. The Gastrointestinal Tumor Study Group experience

31 March 2020

1 reference

Prognostic factors in advanced colorectal carcinoma. Importance of lactic dehydrogenase level, performance status, and white blood cell count

31 March 2020

1 reference

Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer

31 March 2020

1 reference

ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer

31 March 2020

1 reference

Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

1 reference

Genetic alterations during colorectal-tumor development

31 March 2020

1 reference

Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study.

31 March 2020

1 reference

Targeting RAS signalling pathways in cancer therapy

31 March 2020

1 reference

Network analysis of oncogenic Ras activation in cancer

31 March 2020

1 reference

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

31 March 2020

1 reference

Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab

31 March 2020

1 reference

Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer

31 March 2020

1 reference

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

31 March 2020

1 reference

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

31 March 2020

1 reference

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

31 March 2020

1 reference

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

31 March 2020

1 reference

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

31 March 2020

1 reference

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

31 March 2020

1 reference

RAF/RAS oncogenes and mismatch-repair status

31 March 2020

1 reference

Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability

31 March 2020

1 reference

APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.

31 March 2020

1 reference

Expression of non-membranous beta-catenin and gamma-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas.

31 March 2020

1 reference

Cadherin-catenin expression in primary colorectal cancer: a survival analysis

31 March 2020

1 reference

The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment

31 March 2020

1 reference

P53 abnormalities and outcomes in colorectal cancer: a systematic review.

31 March 2020

1 reference

A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis

31 March 2020

1 reference

Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers

31 March 2020

1 reference

Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer.

31 March 2020

1 reference

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

31 March 2020

1 reference

SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer

31 March 2020

1 reference

SMAD4 as a Prognostic Marker in Colorectal Cancer

31 March 2020

1 reference

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

31 March 2020

1 reference

Alternative genetic pathways in colorectal carcinogenesis.

31 March 2020

1 reference

Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways

31 March 2020

1 reference

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

31 March 2020

1 reference

Systematic review of microsatellite instability and colorectal cancer prognosis

31 March 2020

1 reference

Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients

31 March 2020

1 reference

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

31 March 2020

1 reference

Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases

31 March 2020

1 reference

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

31 March 2020

1 reference

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations

31 March 2020

1 reference

Poor Survival Associated with theBRAFV600E Mutation in Microsatellite-Stable Colon Cancers

31 March 2020

1 reference

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

31 March 2020

1 reference

The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer

31 March 2020

1 reference

Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers.

31 March 2020

1 reference

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

31 March 2020

1 reference

Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study

31 March 2020

1 reference

High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection

31 March 2020

1 reference

Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.

31 March 2020

1 reference

Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines

31 March 2020

1 reference

Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803

31 March 2020

1 reference

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

31 March 2020

1 reference

Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint

31 March 2020

1 reference

Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis

31 March 2020

1 reference

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

31 March 2020

1 reference

Pharmacogenomics in colorectal cancer

31 March 2020

1 reference

Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.

31 March 2020

1 reference

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

31 March 2020

1 reference

The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil

31 March 2020

1 reference

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity

31 March 2020

1 reference

Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil

31 March 2020

1 reference

Predicting fluorouracil toxicity: can we finally do it?

31 March 2020

1 reference

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

31 March 2020

1 reference

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity

31 March 2020

1 reference

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.

31 March 2020

1 reference

Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.

31 March 2020

1 reference

Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer

31 March 2020

1 reference

The cellular pharmacology of oxaliplatin resistance

31 March 2020

1 reference

Glutathione S-transferase polymorphisms: cancer incidence and therapy

31 March 2020

1 reference

Glutathione S-Transferase P1 Polymorphism (Ile105Val) Predicts Cumulative Neuropathy in Patients Receiving Oxaliplatin-Based Chemotherapy

31 March 2020

1 reference

Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy.

31 March 2020

1 reference

A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer

31 March 2020

1 reference

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

31 March 2020

1 reference

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

31 March 2020

1 reference

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

31 March 2020

1 reference

UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma

31 March 2020

1 reference

Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan

31 March 2020

1 reference

Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas

31 March 2020

1 reference

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

31 March 2020

1 reference

Stage II colon cancer prognosis prediction by tumor gene expression profiling

31 March 2020

1 reference

Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer.

31 March 2020

1 reference

Colon cancer prognosis prediction by gene expression profiling

31 March 2020

1 reference

Development of a clinically feasible molecular assay to predict recurrence of stage II colon cancer

31 March 2020

1 reference

Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer

31 March 2020

1 reference

Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling.

31 March 2020

1 reference

Gene expression profiling of nonneoplastic mucosa may predict clinical outcome of colon cancer patients

31 March 2020

1 reference

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

31 March 2020

1 reference

Diagnostic and prognostic microRNAs in stage II colon cancer.

31 March 2020

1 reference

mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer

31 March 2020

1 reference

False discovery rate, sensitivity and sample size for microarray studies.

31 March 2020

1 reference

Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment

31 March 2020

1 reference

Prediction of cancer outcome with microarrays: a multiple random validation strategy

31 March 2020

1 reference

Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting

31 March 2020

1 reference

Gene-Expression Signatures in Breast Cancer

31 March 2020

1 reference

Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification

31 March 2020

1 reference

Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer

31 March 2020

1 reference

Randomised trials of HIV prevention

31 March 2020

1 reference

Challenges in projecting clustering results across gene expression-profiling datasets

31 March 2020

1 reference

Gene expression profile assays as predictors of recurrence-free survival in early-stage breast cancer: a metaanalysis

31 March 2020

1 reference

Microarrays and molecular research: noise discovery?

31 March 2020

1 reference

Bias as a threat to the validity of cancer molecular-marker research

31 March 2020

1 reference

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

31 March 2020

1 reference

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

31 March 2020

1 reference

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

31 March 2020

1 reference

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

31 March 2020

1 reference

A common variant on chromosome 9p21 affects the risk of myocardial infarction

31 March 2020

1 reference

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

1 reference

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

31 March 2020

1 reference

Cancer-susceptibility genes. Gatekeepers and caretakers

31 March 2020

1 reference

Genomic instability occurs in colorectal carcinomas but not in adenomas

31 March 2020

1 reference

Genomic and epigenetic instability in colorectal cancer pathogenesis

31 March 2020

1 reference

Colorectal cancer and genetic alterations in the Wnt pathway

31 March 2020

1 reference

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

31 March 2020

1 reference

Frameshift mutator mutations

31 March 2020

1 reference

Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours

31 March 2020

1 reference

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

31 March 2020

1 reference

Inactivation of hCDC4 can cause chromosomal instability

31 March 2020

1 reference

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

31 March 2020

1 reference

Epidermal growth factor-related peptides and their receptors in human malignancies

31 March 2020

1 reference

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

31 March 2020

1 reference

Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

31 March 2020

1 reference

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

31 March 2020

1 reference

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer

31 March 2020

1 reference

Metabolism and mechanism of action of 5-fluorouracil

31 March 2020

1 reference

Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study

31 March 2020

1 reference

12 December 2020

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma

1 reference

12 December 2020

Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

1 reference

12 December 2020

Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.

1 reference

12 December 2020

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

1 reference

12 December 2020

Classification of Dukes' B and C colorectal cancers using expression arrays

1 reference

12 December 2020

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression

1 reference

12 December 2020

A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients

1 reference

12 December 2020

Chemotherapeutic implications in microsatellite unstable colorectal cancer

1 reference

12 December 2020

Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy

1 reference

12 December 2020

Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.

1 reference

12 December 2020

A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity

1 reference

12 December 2020

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer

1 reference

12 December 2020

Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer

1 reference

12 December 2020

Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2645

1 reference

20 August 2017

1 reference