(Q37535502)

20 August 2017

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title

Genomics of type 2 diabetes mellitus: implications for the clinician (English)

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20 August 2017

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Elliot S Stolerman

1

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20 August 2017

Jose C Florez

series ordinal

2

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20 August 2017

language of work or name

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30 June 2009

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Nature Reviews Endocrinology

20 August 2017

published in

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20 August 2017

volume

5

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20 August 2017

issue

8

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20 August 2017

page(s)

429-436

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https://scigraph.springernature.com/pub.10.1038/nrendo.2009.129

20 August 2017

exact match

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cites work

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

31 March 2020

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TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

31 March 2020

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The new type 2 diabetes gene TCF7L2

31 March 2020

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

31 March 2020

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Common variants in WFS1 confer risk of type 2 diabetes

31 March 2020

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Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

31 March 2020

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Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes

31 March 2020

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Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

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A genome-wide association study identifies novel risk loci for type 2 diabetes

31 March 2020

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Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

31 March 2020

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

31 March 2020

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

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31 March 2020

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

31 March 2020

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31 March 2020

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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

31 March 2020

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31 March 2020

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31 March 2020

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A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

31 March 2020

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A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

31 March 2020

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

31 March 2020

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Variants in MTNR1B influence fasting glucose levels

31 March 2020

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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

31 March 2020

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31 March 2020

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A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

31 March 2020

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

31 March 2020

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Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

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31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Genetic cause of hyperglycaemia and response to treatment in diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Genotype score in addition to common risk factors for prediction of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Clinical risk factors, DNA variants, and the development of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.129

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19564886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19564886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRENDO.2009.129

1 reference

20 August 2017

1 reference