(Q37564205)

English

The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials

scientific article published on August 2009

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scholarly article

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Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials (English)

1 reference

Europe PubMed Central

21 August 2017

medulloblastoma

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author name string

Barry L Pizer

1

1 reference

Europe PubMed Central

21 August 2017

Steven C Clifford

2

1 reference

Europe PubMed Central

21 August 2017

publication date

1 August 2009

1 reference

Europe PubMed Central

21 August 2017

British Journal of Neurosurgery

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Europe PubMed Central

21 August 2017

23

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Europe PubMed Central

21 August 2017

4

1 reference

Europe PubMed Central

21 August 2017

364-375

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Europe PubMed Central

21 August 2017

Primitive neuroectodermal tumors of the brain in children

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Prediction of central nervous system embryonal tumour outcome based on gene expression

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Effects of medulloblastoma resections on outcome in children: a report from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Improvements in the radiotherapy of medulloblastoma, 1946-1975.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Posterior fossa boost in medulloblastoma: an analysis of dose to surrounding structures using 3-dimensional (conformal) radiotherapy.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Outcome for patients with metastatic (M2-3) medulloblastoma treated with SIOP/UKCCSG PNET-3 chemotherapy

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The 2007 WHO classification of tumours of the central nervous system

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

APC mutations in sporadic medulloblastomas

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The molecular basis of Turcot's syndrome

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The incidence of Gorlin syndrome in 173 consecutive cases of medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Brain tumor-polyposis syndrome: two genetic diseases?

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The origins of medulloblastoma subtypes

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Medulloblastoma: developmental mechanisms out of control

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The Hedgehog and Wnt signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Axin and hepatocellular carcinomas.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

beta-catenin signaling and cancer

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

AXIN1 mutations but not deletions in cerebellar medulloblastomas.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The developmental biology of brain tumors.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Mutations in SUFU predispose to medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Loss of suppressor-of-fused function promotes tumorigenesis.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

PDGFRB is overexpressed in metastatic medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Structural chromosomal abnormalities in human medulloblastoma.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Clinical and molecular stratification of disease risk in medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

What's new in neuro-oncology? Recent advances in medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Medulloblastoma growth inhibition by hedgehog pathway blockade

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas.

1 reference

https://api.crossref.org/works/10.1080%2F02688690903121807

21 January 2018

Identifiers

10.1080/02688690903121807

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

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