(Q37574419)

21 August 2017

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title

Gene therapy for neurodegenerative diseases based on lentiviral vectors (English)

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21 August 2017

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Aikaterini Nanou

1

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21 August 2017

Mimoun Azzouz

series ordinal

2

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21 August 2017

publication date

1 January 2009

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Progress in Brain Research

21 August 2017

published in

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21 August 2017

volume

175

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21 August 2017

page(s)

187-200

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Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice

21 August 2017

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Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model.

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Neurotrophic factors and amyotrophic lateral sclerosis

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Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

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A Drosophila model of Parkinson's disease

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Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

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7 January 2021

Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct.

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7 January 2021

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

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7 January 2021

Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease

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Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector

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7 January 2021

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

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7 January 2021

Mechanisms of neurodegeneration in Huntington's disease.

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7 January 2021

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

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7 January 2021

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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7 January 2021

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

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7 January 2021

Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1

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7 January 2021

A mouse model for spinal muscular atrophy

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7 January 2021

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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7 January 2021

Development of a novel fusogenic viral liposome system (HVJ-liposomes) and its applications to the treatment of acquired diseases

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7 January 2021

Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein

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AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

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7 January 2021

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7 January 2021

A novel nuclear structure containing the survival of motor neurons protein

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7 January 2021

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

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7 January 2021

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

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7 January 2021

SMN oligomerization defect correlates with spinal muscular atrophy severity

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7 January 2021

A cellular model that recapitulates major pathogenic steps of Huntington's disease

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7 January 2021

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

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7 January 2021

Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.

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7 January 2021

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7 January 2021

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins

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7 January 2021

Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q

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7 January 2021

Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins.

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7 January 2021

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy

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7 January 2021

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

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7 January 2021

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7 January 2021

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

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7 January 2021

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

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7 January 2021

Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes

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7 January 2021

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

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7 January 2021

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

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7 January 2021

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

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7 January 2021

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

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7 January 2021

Intrastriatal injections of quinolinic acid or kainic acid: differential patterns of cell survival and the effects of data analysis on outcome

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7 January 2021

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

Spinal muscular atrophy: clinical classification and disease heterogeneity

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7 January 2021

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

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7 January 2021

Molecular and cellular pathways of neurodegeneration in motor neurone disease

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

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7 January 2021

Valproic acid increases SMN levels in spinal muscular atrophy patient cells.

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7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

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7 January 2021

6-hydroxy-dopamine induced degeneration of central monoamine neurons

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7 January 2021

Neuropathology in mice expressing human alpha-synuclein

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

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7 January 2021

Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies

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7 January 2021

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

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7 January 2021

Motor neuron disease (amyotrophic lateral sclerosis).

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7 January 2021

Transduction Patterns of Pseudotyped Lentiviral Vectors in the Nervous System

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Towards a transgenic model of Huntington's disease in a non-human primate

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7 January 2021

The Relationship between SMN, the Spinal Muscular Atrophy Protein, and Nuclear Coiled Bodies in Differentiated Tissues and Cultured Cells

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7 January 2021

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

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7 January 2021

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

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7 January 2021

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

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7 January 2021

Glutamine repeats and neurodegeneration

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7 January 2021

10.1016/S0079-6123(09)17513-1

Identifiers

DOI

1 reference

21 August 2017

1 reference