(Q78571001)

English

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat

scientific article published on 01 December 2002

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scholarly article

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15 December 2019

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease (English)

1 reference

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15 December 2019

author name string

Mimoun Azzouz

1

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15 December 2019

Enca Martin-Rendon

2

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15 December 2019

Robert D Barber

3

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15 December 2019

Kyriacos A Mitrophanous

4

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15 December 2019

Emma E Carter

5

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15 December 2019

Jonathan B Rohll

6

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15 December 2019

Susan M Kingsman

7

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15 December 2019

Alan J Kingsman

8

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15 December 2019

Nicholas D Mazarakis

9

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15 December 2019

publication date

1 December 2002

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15 December 2019

Journal of Neuroscience

1 reference

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15 December 2019

22

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15 December 2019

10302-10312

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15 December 2019

23

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15 December 2019

Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional integration of neural grafts in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable gene transfer to the nervous system using a non-primate lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentiviral gene transfer to the nonhuman primate brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist stimulation provokes dendritic and axonal dopamine D(1) receptor redistribution in primary cultures of striatal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of embryonic dopamine neurons for severe Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy for Parkinson's disease: determining the genes necessary for optimal dopamine replacement in rat models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentiviral vectors for the treatment of neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-synuclein and cytosolic dopamine: stabilizing a bad situation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, production, safety, evaluation, and clinical applications of nonprimate lentiviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New methods to titrate EIAV-based lentiviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of nuclear population from microtome sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinsonism: onset, progression, and mortality

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CFTR as a cAMP-dependent regulator of sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific Patterns of Defective HSV-1 Gene Transfer in the Adult Central Nervous System: Implications for Gene Targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transient three-plasmid expression system for the production of high titer retroviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intricate regulation of tyrosine hydroxylase activity and gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GTP cyclohydrolase I gene, dystonia, juvenile parkinsonism, and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-induced morphologic decrease in cellular D1A dopamine receptor staining

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization of D1 dopamine receptor in striatal neurons in vivo as evidence of activation by dopamine agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction and characterization of single-transcript tricistronic retroviral vectors using two internal ribosome entry sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12451130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-23-10302.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12451130%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12451130%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12451130%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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