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Designed Hsp90 heterodimers reveal an asymmetric ATPase-driven mechanism in vivo.
scientific article published on January 2014
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Europe PubMed Central
PMC publication ID
3923517
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
title
Designed Hsp90 heterodimers reveal an asymmetric ATPase-driven mechanism in vivo
(English)
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PMC publication ID
3923517
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
author
Daniel Bolon
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2
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PMC publication ID
3923517
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6 March 2020
author name string
Parul Mishra
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1
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Europe PubMed Central
PMC publication ID
3923517
reference URL
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retrieved
6 March 2020
publication date
1 January 2014
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3923517
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retrieved
6 March 2020
published in
Molecular Cell
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PMC publication ID
3923517
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
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6 March 2020
volume
53
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Europe PubMed Central
PMC publication ID
3923517
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
issue
2
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Europe PubMed Central
PMC publication ID
3923517
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
page(s)
344-350
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Europe PubMed Central
PMC publication ID
3923517
reference URL
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6 March 2020
cites work
Shifting fitness landscapes in response to altered environments.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Latent effects of Hsp90 mutants revealed at reduced expression levels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Heat shock protein 90's mechanochemical cycle is dominated by thermal fluctuations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Substrate Binding Drives Large-Scale Conformational Changes in the Hsp90 Molecular Chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Experimental illumination of a fitness landscape
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Modular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Structure of an Hsp90-Cdc37-Cdk4 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
GHKL, an emergent ATPase/kinase superfamily
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Steroid receptor interactions with heat shock protein and immunophilin chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
23 August 2017
The chaperone Hsp90: changing partners for demanding clients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
6 September 2017
Hsp90-mediated folding of the lymphoid cell kinase p56lck
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
28 September 2017
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
28 September 2017
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
25 June 2018
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
25 June 2018
The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Automated design of specificity in molecular recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Coordinated ATP hydrolysis by the Hsp90 dimer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923517
retrieved
1 September 2018
Coupled assay of Na+,K+-ATPase activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24462207
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24462207
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24462207
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLCEL.2013.12.024
1 reference
stated in
Europe PubMed Central
PMC publication ID
3923517
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
PMC publication ID
3923517
1 reference
stated in
Europe PubMed Central
PMC publication ID
3923517
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
PubMed publication ID
24462207
1 reference
stated in
Europe PubMed Central
PMC publication ID
3923517
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462207%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
ResearchGate publication ID
259916855
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