(Q41792117)

10 October 2017

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. (English)

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Hsp90 family chaperone HSP82 YPL240C

10 October 2017

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GOA release 2020-03-11

Franz Hagn

1

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Klaus Richter

object named as

Klaus Richter

6

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author name string

Stephan Lagleder

2

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10 October 2017

Marco Retzlaff

3

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10 October 2017

Julia Rohrberg

4

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10 October 2017

Oliver Demmer

5

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10 October 2017

Johannes Buchner

7

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10 October 2017

Horst Kessler

8

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10 October 2017

4 September 2011

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Nature Structural & Molecular Biology

10 October 2017

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10 October 2017

18

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10 October 2017

10

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10 October 2017

1086-1093

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https://scigraph.springernature.com/pub.10.1038/nsmb.2114

10 October 2017

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cites work

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

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Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

21 January 2018

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The Hsp90 chaperone machinery

21 January 2018

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Substrate transfer from the chaperone Hsp70 to Hsp90.

21 January 2018

1 reference

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

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The middle domain of Hsp90 acts as a discriminator between different types of client proteins

21 January 2018

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Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

21 January 2018

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Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

21 January 2018

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The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

21 January 2018

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Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

21 January 2018

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The client protein p53 adopts a molten globule-like state in the presence of Hsp90.

21 January 2018

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CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

21 January 2018

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Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone

21 January 2018

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p53--a natural cancer killer: structural insights and therapeutic concepts

21 January 2018

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T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

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Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

21 January 2018

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HSP90 and the chaperoning of cancer

21 January 2018

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Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

21 January 2018

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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

21 January 2018

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The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

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Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

21 January 2018

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Conserved conformational changes in the ATPase cycle of human Hsp90.

21 January 2018

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NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

21 January 2018

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Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

21 January 2018

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TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins

21 January 2018

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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

21 January 2018

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Mechanism of coupled folding and binding of an intrinsically disordered protein

21 January 2018

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

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Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

21 January 2018

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Validation of Protein Structure from Anisotropic Carbonyl Chemical Shifts in a Dilute Liquid Crystalline Phase

21 January 2018

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BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain

21 January 2018

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

21 January 2018

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Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

21 January 2018

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Charge-rich regions modulate the anti-aggregation activity of Hsp90.

21 January 2018

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ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein

21 January 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

21 January 2018

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Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

21 January 2018

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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

21 January 2018

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A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone

21 January 2018

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

21 January 2018

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Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

21 January 2018

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Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

21 January 2018

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The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

21 January 2018

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Preparative scale expression of membrane proteins in Escherichia coli-based continuous exchange cell-free systems.

21 January 2018

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SEDVIEW, real-time sedimentation analysis.

21 January 2018

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Automated backbone assignment of labeled proteins using the threshold accepting algorithm.

21 January 2018

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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

21 January 2018

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Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium

21 January 2018

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Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions

21 January 2018

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The Xplor-NIH NMR molecular structure determination package

21 January 2018

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The HADDOCK web server for data-driven biomolecular docking

21 January 2018

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HYDRONMR: prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations.

21 January 2018

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

21 January 2018

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Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge

31 March 2020

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Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2114

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Dimensions Publication ID

10 October 2017

1021694801

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Fatcat ID

release_bdatvqv2njelhadgvdkrtr5q2u

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Fatcat

https://api.fatcat.wiki/v0/release/bdatvqv2njelhadgvdkrtr5q2u

mapped directly with Wikidata item

24 November 2022

based on heuristic

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