(Q37591118)

English

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.

scientific article published on 27 December 2013

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scholarly article

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3 March 2020

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 (English)

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3 March 2020

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Stilianos Antonarakis

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Federico A Santoni

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Youssef Hibaoui

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Audrey Letourneau

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M Reza Sailani

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Sophie Dahoun

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Stefania Gimelli

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Michel Guipponi

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Marie Francoise Pelte

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Frédérique Béna

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27 December 2013

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EMBO Molecular Medicine

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259-277

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describes a project that uses

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Twin-N-iPSCs line#8

0 references

1 reference

Europe PubMed Central

11 June 2022

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object named as

EdgeR

1 reference

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DESeq

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

1 reference

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Human pluripotent stem cells: applications and challenges in neurological diseases.

1 reference

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23 August 2017

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

1 reference

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NANOG priming before full reprogramming may generate germ cell tumours

2 references

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23 August 2017

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7 January 2021

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inferred from DOI database lookup

The use of mouse models to understand and improve cognitive deficits in Down syndrome

1 reference

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1 reference

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S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors

1 reference

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Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

1 reference

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1 reference

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1 reference

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Modelling schizophrenia using human induced pluripotent stem cells

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Differential expression analysis for sequence count data

1 reference

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23 August 2017

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

23 August 2017

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

1 reference

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Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes

1 reference

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Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells

1 reference

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Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells

1 reference

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23 August 2017

REST and CoREST modulate neuronal subtype specification, maturation and maintenance

1 reference

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23 August 2017

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1 reference

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23 August 2017

A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

1 reference

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23 August 2017

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

1 reference

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23 August 2017

Fast and accurate short read alignment with Burrows-Wheeler transform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

23 August 2017

Human induced pluripotent stem cells free of vector and transgene sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

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Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors

1 reference

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

23 August 2017

Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

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1 reference

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Disease-specific induced pluripotent stem cells

1 reference

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Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly

1 reference

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Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus

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1 reference

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1 reference

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1 reference

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1 reference

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

1 reference

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1 reference

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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

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Growth and development of the brain in Down syndrome

1 reference

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1 reference

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6 September 2017

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

1 reference

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1 September 2018

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1 reference

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1 September 2018

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice.

1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

1 September 2018

Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

1 September 2018

Developmental changes of S-100 protein and glial fibrillary acidic protein in the brain in Down syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927959

1 September 2018

Monozygotic twins discordant for trisomy 21 and maternal 21q inheritance: A complex series of events

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201302848

21 January 2018

Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53- and CD95-associated apoptosis in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24375627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/EMMM.201302848

1 reference

Europe PubMed Central

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

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