(Q48709346)

14 February 2018

title

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice (English)

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14 February 2018

author name string

Bozena Mazur-Kolecka

1

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14 February 2018

Adam Golabek

2

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14 February 2018

Elizabeth Kida

3

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14 February 2018

Ausma Rabe

4

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14 February 2018

Yu-Wen Hwang

5

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14 February 2018

Tatyana Adayev

6

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14 February 2018

Jerzy Wegiel

7

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14 February 2018

Michael Flory

8

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14 February 2018

Wojciech Kaczmarski

9

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14 February 2018

Elaine Marchi

10

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14 February 2018

Janusz Frackowiak

11

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14 February 2018

publication date

18 January 2012

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14 February 2018

Journal of Neuroscience Research

published in

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14 February 2018

volume

90

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14 February 2018

issue

5

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14 February 2018

page(s)

999-1010

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14 February 2018

The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development.

cites work

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Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

21 January 2018

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

21 January 2018

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

21 January 2018

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DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

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REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

21 January 2018

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The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

21 January 2018

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On dendrites in Down syndrome and DS murine models: a spiny way to learn.

21 January 2018

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Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

21 January 2018

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KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.

21 January 2018

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Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo

21 January 2018

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DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

21 January 2018

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Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

21 January 2018

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Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

21 January 2018

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Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice

21 January 2018

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Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

21 January 2018

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Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

21 January 2018

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DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis.

21 January 2018

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Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

21 January 2018

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GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states

21 January 2018

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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

21 January 2018

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Up-regulation of ciliary neurotrophic factor receptor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain

21 January 2018

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GABA regulates synaptic integration of newly generated neurons in the adult brain

21 January 2018

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Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

21 January 2018

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

21 January 2018

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Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

21 January 2018

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Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions.

21 January 2018

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The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.

21 January 2018

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Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

21 January 2018

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Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals.

21 January 2018

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Inhibition of monoamine oxidase A by beta-carboline derivatives

21 January 2018

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A small modulatory dsRNA specifies the fate of adult neural stem cells

21 January 2018

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The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

21 January 2018

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DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

21 January 2018

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Prenatal GABAB1 and GABAB2 receptors: cellular and subcellular organelle localization in early fetal rat cortical neurons

21 January 2018

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Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

21 January 2018

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Developing oligodendrocytes express functional GABA(B) receptors that stimulate cell proliferation and migration

21 January 2018

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Amyloid-beta impairs development of neuronal progenitor cells by oxidative mechanisms

21 January 2018

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Sera from children with autism alter proliferation of human neuronal progenitor cells exposed to oxidation.

21 January 2018

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Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly

21 January 2018

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Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles

21 January 2018

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Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

21 January 2018

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Increased levels of carbonic anhydrase II in the developing Down syndrome brain.

21 January 2018

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Function and regulation of Dyrk1A: towards understanding Down syndrome

21 January 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

21 January 2018

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Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII

21 January 2018

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Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

21 January 2018

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Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

21 January 2018

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DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

21 January 2018

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REST maintains self-renewal and pluripotency of embryonic stem cells

21 January 2018

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

21 January 2018

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Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine

21 January 2018

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Distinct profiles of REST interactions with its target genes at different stages of neuronal development

21 January 2018

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Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change

21 January 2018

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minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

21 January 2018

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GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells

21 January 2018

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Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.

21 January 2018

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Defining the role of GABA in cortical development.

21 January 2018

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GABA depolarizes neuronal progenitors of the postnatal subventricular zone via GABAA receptor activation

21 January 2018

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Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain

21 January 2018

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SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation

21 January 2018

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Down syndrome--recent progress and future prospects

21 January 2018

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Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells

21 January 2018

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Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.23007

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14 February 2018

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14 February 2018