(Q37604387)

21 August 2017

1 reference

title

Apoptosis: a clinically useful measure of antiretroviral drug toxicity? (English)

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21 August 2017

main subject

anti-retroviral agent

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author name string

David James Hooker

series ordinal

1

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21 August 2017

Catherine Louise Cherry

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 December 2009

1 reference

Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

published in

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21 August 2017

volume

5

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21 August 2017

issue

12

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21 August 2017

page(s)

1543-1553

1 reference

The effect of highly active antiretroviral therapy on mortality among HIV-infected former plasma donors in China.

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study. Swiss HIV Cohort Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Human immunodeficiency virus neurological complications: an overview of the Ugandan experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural Uganda

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV lipodystrophy: prevalence, severity and correlates of risk in Australia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

High prevalence of lipoatrophy among patients on stavudine-containing first-line antiretroviral therapy regimens in Rwanda

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial toxicity of antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Management of hyperlactatemia: no need for routine lactate measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Hyperlactatemia in human immunodeficiency virus-infected children receiving antiretroviral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mild to moderate symptoms do not correlate with lactate levels in HIV-positive patients on nucleoside reverse transcriptase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Frequency, risk factors, and outcome of hyperlactatemia in HIV-positive persons: implications for the management of treated patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Anaerobic threshold and random venous lactate levels among HIV-positive patients on antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Natural history of hyperlactataemia in human immunodeficiency virus-1-infected patients during highly active antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Higher-than-expected rates of lactic acidosis among highly active antiretroviral therapy-treated women in Botswana: preliminary results from a large randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

[13C]Methionine breath test: a novel method to detect antiretroviral drug-related mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Increased red cell corpuscular volume and hepatic mitochondrial function in NRTI-treated HIV infected patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Quantitative analysis of human mitochondrial DNA using a real-time PCR assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Assessment of precision and concordance of quantitative mitochondrial DNA assays: a collaborative international quality assurance study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Analysis of the mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with or without lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Greater and more rapid depletion of mitochondrial DNA in blood of patients treated with dual (zidovudine+didanosine or zidovudine+zalcitabine) vs. single (zidovudine) nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Changes in mitochondrial DNA copy number in blood cells from HIV-infected patients undergoing antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial DNA content, an inaccurate biomarker of mitochondrial alteration in human immunodeficiency virus-related lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Apoptosis in the pathogenesis and treatment of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV protease inhibitors modulate apoptosis signaling in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Lymphocyte mitochondrial depolarization and apoptosis in HIV-1-infected HAART patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Ultrastructural features of highly active antiretroviral therapy-associated partial lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV protease inhibitors impact on apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

In vitro and in vivo effects of HIV protease inhibitors on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Changes of lymphocyte apoptosis associated with sequential introduction of highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Nucleoside reverse transcriptase inhibitors and human immunodeficiency virus proteins cause axonal injury in human dorsal root ganglia cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondrial myopathy caused by long-term zidovudine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Clinical, histological and molecular reversibility of zidovudine myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV-1 viral genes and mitochondrial apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Death ligand-mediated apoptosis in HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

New insights on the role of apoptosis and autophagy in HIV pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV induces thymus depletion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV preferentially infects HIV-specific CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Perils at mucosal front lines for HIV and SIV and their hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Induction of "tissue" transglutaminase in HIV pathogenesis: evidence for high rate of apoptosis of CD4+ T lymphocytes and accessory cells in lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

The neuropathogenesis of AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

HIV-associated sensory neuropathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Antiretroviral-therapy-associated lipoatrophy: current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Death receptor signals to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Analysis of apoptotic pathways by multiparametric flow cytometry: application to HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Mitochondria play no roles in Mn(II)-induced apoptosis in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Measuring and monitoring apoptosis and drug toxicity in HIV patients by ligation-mediated polymerase chain reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Apoptotic markers in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Cytochrome c: a non-invasive biomarker of drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Metabolic and Skeletal Complications of HIV Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Effect of the Substitution of One Nucleoside Analogue by One Non-nucleoside Reverse Transcriptase Inhibitor over Mitochondrial DNA Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Class of Antiretroviral Drugs and the Risk of Myocardial Infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903282781

Cell Death in Development

21 January 2018

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0092-8674(00)80564-4

Identifiers

DOI

10.1517/17425250903282781

1 reference

21 August 2017

1 reference