(Q37634512)

21 August 2017

1 reference

title

Long term adverse effects related to nucleoside reverse transcriptase inhibitors: clinical impact of mitochondrial toxicity (English)

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21 August 2017

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2

Dag Kvale

1 reference

21 August 2017

Anne Maagaard

1

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21 August 2017

publication date

1 January 2009

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Scandinavian Journal of Infectious Diseases

21 August 2017

published in

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21 August 2017

volume

41

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21 August 2017

issue

11-12

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21 August 2017

page(s)

808-817

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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

21 August 2017

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A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

21 January 2018

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A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.

21 January 2018

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Combination antiretroviral therapy and the risk of myocardial infarction

21 January 2018

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Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

21 January 2018

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Mitochondrial toxicity of antiviral drugs

21 January 2018

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Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

21 January 2018

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Mitochondrial myopathy caused by long-term zidovudine therapy

21 January 2018

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Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy

21 January 2018

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Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults

21 January 2018

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The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infection

21 January 2018

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21 January 2018

Mitochondrial myopathies

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DNA polymerase gamma in mitochondrial DNA replication and repair.

21 January 2018

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Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

21 January 2018

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Mitochondrial membrane permeabilization in cell death

21 January 2018

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The apoptosome: signalling platform of cell death

21 January 2018

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Mitochondrial diseases in man and mouse

21 January 2018

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Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

The genetics and pathology of oxidative phosphorylation

21 January 2018

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https://api.crossref.org/works/10.3109%2F00365540903186181

The structure and replication of kinetoplast DNA

21 January 2018

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https://api.crossref.org/works/10.3109%2F00365540903186181

DNA replication and transcription in mammalian mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

21 January 2018

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https://api.crossref.org/works/10.3109%2F00365540903186181

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00365540903186181

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Analysis of the mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with or without lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Management of hyperlactatemia: no need for routine lactate measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Short communication: reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Risk factors for and outcome of hyperlactatemia in HIV-infected persons: is there a need for routine lactate monitoring?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Risk factors for lactic acidosis in HIV-infected patients treated with nucleoside reverse-transcriptase inhibitors: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Nucleoside analogues and mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Adverse effects of antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Redefining lipodystrophy syndrome: risks and impact on clinical decision making

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial DNA depletion in adipose tissue of HIV-infected patients with peripheral lipoatrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Role of mitochondria in HIV lipoatrophy: insight into pathogenesis and potential therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: the MITOX Extension Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Distinct mechanisms for mitochondrial DNA loss in T and B lymphocytes from HIV-infected patients exposed to nucleoside reverse-transcriptase inhibitors and those naive to antiretroviral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Unexpected evidence for active brown adipose tissue in adult humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Fat distribution and metabolic changes are strongly correlated and energy expenditure is increased in the HIV lipodystrophy syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Lipodystrophy and metabolic syndrome in HIV-infected patients treated with antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Lactic acidosis associated with stavudine administration: a report of five cases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mechanisms of zidovudine-induced mitochondrial toxicity and myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial dynamics in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondria: dynamic organelles in disease, aging, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Fanconi syndrome and renal failure induced by tenofovir: a first case report

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Proximal tubular kidney damage and tenofovir: a role for mitochondrial toxicity?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Unexpected drug interactions and adverse events with antiretroviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Sex differences in antiretroviral therapy toxicity: lactic acidosis, stavudine, and women

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Depletion of mitochondrial DNA copies/cell in peripheral blood mononuclear cells in HIV-1-infected treatment-naïve patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Mitochondrial DNA content, an inaccurate biomarker of mitochondrial alteration in human immunodeficiency virus-related lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

Class of Antiretroviral Drugs and the Risk of Myocardial Infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00365540903186181

10.3109/00365540903186181

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference