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The mitochondrial DNA polymerase in health and disease.
scientific article published on January 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
The mitochondrial DNA polymerase in health and disease
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
main subject
mitochondrial DNA
0 references
mitochondrion
1 reference
based on heuristic
inferred from title
author
William C Copeland
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
author name string
William C Copeland
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3960799
retrieved
21 August 2017
publication date
1 January 2010
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
published in
Sub-cellular biochemistry
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
volume
50
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
211-222
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
cites work
DNA2 resolves expanding flap in mitochondrial base excision repair
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Long patch base excision repair in mammalian mitochondrial genomes
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PubMed Central
reference URL
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23 August 2017
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations
1 reference
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PubMed Central
reference URL
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23 August 2017
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria
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23 August 2017
Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders
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23 August 2017
DNA polymerases and human diseases
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23 August 2017
DNA polymerase gamma in mitochondrial DNA replication and repair.
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PubMed Central
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23 August 2017
Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Mitochondrial DNA and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Functions of DNA polymerases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Reconstitution of a minimal mtDNA replisome in vitro
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Mitochondrial diseases in man and mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Mitochondrial myopathy caused by long-term zidovudine therapy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Q28323629
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
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23 August 2017
Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Selective action of 2',3'-didehydro-2',3'-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
23 August 2017
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
6 September 2017
The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
14 September 2017
Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
14 September 2017
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
28 September 2017
Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
25 June 2018
Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
25 June 2018
Properties of the 3' to 5' exonuclease associated with porcine liver DNA polymerase gamma. Substrate specificity, product analysis, inhibition, and kinetics of terminal excision.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
25 June 2018
Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
25 June 2018
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Multiple oxidative phosphorylation deficiencies in severe childhood multi-system disorders due to polymerase gamma (POLG1) mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Molecular diagnosis of Alpers syndrome.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960799
retrieved
1 September 2018
Patient homozygous for a recessive POLG mutation presents with features of MERRF
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20012584
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20012584
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20012584
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20012584
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/978-90-481-3471-7_11
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PMCID
3960799
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed ID
20012584
1 reference
stated in
Europe PubMed Central
PMCID
3960799
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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