(Q38354757)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs (English)

1 reference

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3 November 2019

4

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3 November 2019

author name string

Susan E Lim

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Mikhail V Ponamarev

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Matthew J Longley

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

0 references

publication date

1 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

Journal of Molecular Biology

3 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

329

1 reference

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3 November 2019

issue

1

1 reference

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3 November 2019

page(s)

45-57

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

3 November 2019

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7 January 2021

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Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

7 January 2021

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Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase

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Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

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Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence?

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Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

7 January 2021

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Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

7 January 2021

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Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

7 January 2021

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Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma

7 January 2021

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Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity

7 January 2021

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Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase

7 January 2021

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An attempt to unify the structure of polymerases

7 January 2021

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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

7 January 2021

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

7 January 2021

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

7 January 2021

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Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

7 January 2021

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Yeast mitochondrial DNA polymerase is related to the family A DNA polymerases

7 January 2021

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Compilation and alignment of DNA polymerase sequences

7 January 2021

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

7 January 2021

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

7 January 2021

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The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

7 January 2021

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A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides

7 January 2021

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How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides

7 January 2021

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Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).

7 January 2021

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Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)

7 January 2021

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The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

7 January 2021

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A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

7 January 2021

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Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain

7 January 2021

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Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

7 January 2021

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Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

7 January 2021

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Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

7 January 2021

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Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection

7 January 2021

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A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides

7 January 2021

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The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

7 January 2021

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Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine

7 January 2021

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Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

7 January 2021

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Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

7 January 2021

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7 January 2021

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7 January 2021

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Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts

7 January 2021

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 January 2021

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10.1016/S0022-2836(03)00405-4

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12742017%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference