(Q44113743)

English

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

scientific article published on 22 August 2002

The Molecular Mechanism of Multidrug Resistance by the Q151M Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Its Suppression Using α-Boranophosphate Nucleotide Analogues

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scholarly article

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Europe PubMed Central

29 November 2017

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues (English)

1 reference

Europe PubMed Central

29 November 2017

multiple drug resistance

1 reference

based on heuristic

inferred from title

7

object named as

Bruno Canard

1 reference

Europe PubMed Central

29 November 2017

author name string

Jerome Deval

1

1 reference

Europe PubMed Central

29 November 2017

Boulbaba Selmi

2

1 reference

Europe PubMed Central

29 November 2017

Joelle Boretto

3

1 reference

Europe PubMed Central

29 November 2017

Marie Pierre Egloff

4

1 reference

Europe PubMed Central

29 November 2017

Catherine Guerreiro

5

1 reference

Europe PubMed Central

29 November 2017

Simon Sarfati

6

1 reference

Europe PubMed Central

29 November 2017

language of work or name

0 references

publication date

22 August 2002

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Europe PubMed Central

29 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

29 November 2017

277

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Europe PubMed Central

29 November 2017

44

1 reference

Europe PubMed Central

29 November 2017

42097-42104

1 reference

Europe PubMed Central

29 November 2017

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Slow rate of phosphodiester bond formation accounts for the strong bias that Taq DNA polymerase shows against 2',3'-dideoxynucleotide terminators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Drug resistance and heterogeneous long-term virologic responses of human immunodeficiency virus type 1-infected subjects to zidovudine and didanosine combination therapy. The AIDS Clinical Trials Group 143 Virology Team

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206725200

21 January 2018

Identifiers

10.1074/JBC.M206725200

1 reference

Europe PubMed Central

29 November 2017

1 reference

Europe PubMed Central

29 November 2017

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